Natural Product Reports

RSC – Nat. Prod. Rep. latest articles

• Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics Tháng Hai 20, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00064A, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Morgane Mauduit, Stéphane Greff, Marie Derrien, Charlotte SimmlerThis review highlights advances in characterizing exometabolites (EMs) from benthic organisms, starting with in situ sampling methods, then discussing how marine MS-based (exo)metabolomics benefits various […]
  Morgane Mauduit
• Harnessing microbial co-culture to increase the production of known secondary metabolites Tháng Hai 19, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00052H, Review ArticleYu-Zhen Li, Wan-Qi Zhang, Peng-Fei Hu, Qiong-Qiong Yang, István Molnár, Peng Xu, Bo-Bo ZhangCo-culturing may provoke the biosynthesis of novel natural products. However, various microbial co-culture techniques may also boost the fermentation titer, yield and rate of known natural products – we review current progress towards such […]
  Yu-Zhen Li
• Fatty acyl-AMP ligases in bacterial natural product biosynthesis Tháng Hai 19, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00073K, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anne Liong, Pedro N. LeãoFAAL enzymes play a crucial role in the biosynthesis of many natural products containing fatty acids. This review traces the history of FAALs, from their initial discovery to […]
  Anne Liong
• Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery Tháng Hai 14, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00055B, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Paris S. Salazar-Hamm, Frances E. Homan, Shyleigh A. Good, Jennifer J. M. Hathaway, Ashley E. Clements, Evelyn G. Haugh, Lindsay K. CaesarSubterranean microbial communities possess unique and untapped biosynthetic potential.To cite this […]
  Paris S. Salazar-Hamm
• Total synthesis of isoflavonoids Tháng Hai 11, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00060A, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mamoalosi A. Selepe, Siyanda T. Mthembu, Molahlehi S. SonopoThe review is on synthesis of different classes of isoflavonoids that include isoflavones, isoflavanones, isoflavans, isoflavenes, pterocarpans, rotenoids, coumaronochromones, and coumestans.To cite this article […]
  Mamoalosi A. Selepe
• Marine natural products Tháng Hai 6, 2025
  Nat. Prod. Rep., 2025, 42,257-297DOI: 10.1039/D4NP00067F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anthony R. Carroll, Brent R. Copp, Tanja Grkovic, Robert A. Keyzers, Michèle R. PrinsepA comprehensive review of 1220 new MNPs including a novel sex inducing pheromone from the diatom Seminavis robusta.The content of […]
  Anthony R. Carroll
• Hot off the press Tháng Hai 4, 2025
  Nat. Prod. Rep., 2025, 42,203-207DOI: 10.1039/D5NP90004B, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as hyperzrone A from Hypericum beanii.The content of this RSS Feed (c) The Royal Society of Chemistry
  Robert A. Hill
• The role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis Tháng Hai 3, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00048J, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yuya Kakumu, Ayesha Ahmed Chaudhri, Eric J. N. HelfrichThis review explores recent insights into the roles and enzymatic mechanisms of canonical and non-canonical tailoring enzymes in shaping and modifying terpene hydrocarbon scaffolds […]
  Yuya Kakumu
• Advanced crystallography for structure determination of natural products Tháng Hai 3, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00071D, Highlight Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jian-Guo Song, Wen-Cai Ye, Ying WangFour cutting-edge crystallography strategies for structure elucidation of natural products that are difficult to crystallize or in nanocrystalline form.To cite this article before page numbers are assigned, use […]
  Jian-Guo Song
• The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis Tháng Một 27, 2025
  Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00059E, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tobias M. Milzarek, Tobias A. M. GulderSorbicillinoids are a growing class of fungal natural products combining complex molecular architectures with pharmaceutically relevant bioactivities. This review covers their structural diversity, biosynthesis, and synthetic […]
  Tobias M. Milzarek
• Human milk as a complex natural product Tháng Một 20, 2025
  Nat. Prod. Rep., 2025, 42,406-420DOI: 10.1039/D4NP00058G, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Julie A. Talbert, Steven D. TownsendBreastfeeding is one of the most effective ways to promote child health.The content of this RSS Feed (c) The Royal Society of Chemistry
  Julie A. Talbert
• Enzymatic ester bond formation strategies in fungal macrolide skeletons Tháng Một 20, 2025
  Nat. Prod. Rep., 2025, 42,298-323DOI: 10.1039/D4NP00050A, Review ArticleJin-Mei Zhang, Guan-Yin Yuan, Yi ZouThis review mainly focuses on the essential roles of thioesterase and condensation domains in fungal macrolide biosynthesis and their chemoenzymatic applications. It also discusses the differences in ester bond formation between fungi and bacteria.The content of this RSS Feed (c) The Royal Society […]
  Jin-Mei Zhang
• Chemistry and biology of natural stilbenes: an update Tháng Mười Hai 23, 2024
  Nat. Prod. Rep., 2025, 42,359-405DOI: 10.1039/D4NP00033A, Review ArticleLipeng Zhou, Xinyu Cai, Ying Wang, Jianbo Yang, Yadan Wang, Jialing Deng, Danni Ye, Lanzhen Zhang, Yue Liu, Shuangcheng MaStilbenes, an emblematic group of polyphenols, have attracted the attention of numerous researchers owing to their intriguing polycyclic architectures and diverse bioactivities.The content of this RSS Feed (c) The […]
  Lipeng Zhou
• Progress in the discovery and development of anticancer agents from marine cyanobacteria Tháng Mười Hai 2, 2024
  Nat. Prod. Rep., 2025, 42,208-256DOI: 10.1039/D4NP00019F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hendrik Luesch, Emma K. Ellis, Qi-Yin Chen, Ranjala RatnayakeWe describe the pipeline of anticancer agents from marine cyanobacteria, highlighting critical steps from discovery towards development, including the identification of the molecular target and […]
  Hendrik Luesch
• The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture Tháng Mười Một 18, 2024
  Nat. Prod. Rep., 2025, 42,324-358DOI: 10.1039/D4NP00046C, Review ArticleRomain M. M. François, Jean-Malo Massicard, Kira J. WeissmanLarge-scale sequencing has revealed the widespread occurrence of type I polyketides in all kingdoms of life, while co-culturing methods coupled with biochemical analysis have started to tease out their diverse ecological and physiological roles.The content of this RSS Feed (c) […]
  Romain M. M. François