RSC – Org. Biomol. Chem. latest articles- A computational investigation of aromatic oligoamide foldamer binding to sugar molecules Tháng 9 17, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00908A, PaperSamantha Horowitz, Taylor Bryan, Joshua E. Guzman, Sarah Radichel, Ella C. Pickell, Olivia Golebiewski, Yulong Zhong, Daniel P. Miller, Bing GongHelical aromatic oligoamide foldamers (1a–c) with tunable lengths were computationally examined for their ability to bind selected sugars and sugar alcohols.To cite this article before page numbers are […]Samantha Horowitz
- Synthesis of N-Sulfonyl Acetamidines Using Calcium Carbide as an Alkyne Source Tháng 9 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01072A, PaperWei Chen, Zhiqiang Wang, Jinhui Yang, Zheng LiN-Sulfonyl acetamidine moieties are widely present in many biologically active compounds and organometallic complexes, and are particularly used as intermediates in organic synthesis. Herein, a novel and practical method for...The content of this RSS Feed (c) The Royal Society of ChemistryWei Chen
- External Base-free Electrophilic Diynylation of Thiols with Diynyl Benziodoxolone Tháng 9 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01384D, CommunicationRyusei Uozumi, Takuto Naito, Hiroyoshi Esaki, Norihiro Tada, Akichika ItohIn this study, external base-free electrophilic diynylation of thiols to 1,3-butadiynyl sulfide, an important structural motif in organic synthesis, chemical biology, and materials science using triisopropylsilyl diynyl benziodoxolone at room...The content of this RSS Feed (c) The Royal Society […]Ryusei Uozumi
- Facile synthesis of tetrahydrocarbazoles under photocatalyst-free conditions Tháng 9 17, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01143D, CommunicationDong-Xiao Jiang, Zhang Chen, Qing Shu, Yufeng Tan, Jinjin Chen, Xi Zhang, Zhengwen Lei, Zhen Wang, Yao-Fu ZengA visible-light-induced, photocatalyst-free protocol for the preparation of tetrahydrocarbazoles via cascade decarboxylative cyclization of indolyl NHPI esters with alkenes was developed.To cite this article before page numbers are assigned, use the […]Dong-Xiao Jiang
- Efficient synthesis of quinazolinones through base promoted dehydrocyclization using copper (II) catalyst Tháng 9 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01291K, PaperBiswajit Khutia, Debopam Sinha, Sneha Ray, Uday Shee, Kajal Krishna RajakTwo keto-pyrazole based ligands (2a, 2b) having N^N^O chelating Schiff base and its Cu(II) complexes, (Z)-5-methyl-2-phenyl-4-((quinolin-8-ylimino)(p-tolyl)methyl)-pyrazol Cu(II) chloride (3a) and (Z)-5-methyl-2-phenyl-4-((pyridin-2-ylmethyl)imino)(p-tolyl)methyl)-2pyrazol Cu(II) chloride (3b) are reported here. Single-crystal X-ray diffraction...The content of this RSS Feed (c) The Royal […]Biswajit Khutia
- Preparation of poly-N-(methyl)aminooxy serine polypeptides by NCA ring-opening polymerization for modification with reducing oligosaccharides Tháng 9 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00985E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Palmieri, Marlinde D. Waardenburg, Justyna M. Dobruchowska, Elena Roditis, Tina Vermonden, Geert-Jan BoonsN-carboxyanhydride (NCA) ring-opening polymerization offers an attractive approach for the construction of polypeptides. Here, we report the synthesis of a […]Francesco Palmieri
- Transition Metal-Free Stereospecific Di-Chalcogenations of Substituted Acetylenes Tháng 9 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01108F, PaperYen-Ting Chang, Indrajit Karmakar, Rekha Bai, Chin-Fa LeeWe report a one-pot, transition metal-free, stereospecific di-chalcogenation reaction for the synthesis of a diverse range of substituted Z-di-organochalcogenides. This method employs Cs2CO3 as a non-toxic basic catalyst in dimethyl...The content of this RSS Feed (c) The Royal Society of ChemistryYen-Ting Chang
- Perspectives on metal-catalysed syntheses of carbolines (α/β/γ/δ): recent advances Tháng 9 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01250C, Review ArticleSarat Chatterjee, Chinmay ChowdhuryIn this review, we provide a brief yet comprehensive account of the metal-catalysed syntheses of four isomeric carbolines (α/β/γ/δ) along with the mechanistic pathways involved in the aforesaid strategies.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Sarat Chatterjee
- Rhodium-catalyzed ortho-C–H alkylation of benzaldehydes with maleimides free of transient directing groups Tháng 9 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01336D, CommunicationJing-Wen Jia, Wen-Ting Wei, Xiao-Zuan Chen, Xian-Ying ShiA rhodium-catalyzed conjugate addition of C–H bonds to maleimides directed by a weakly coordinating aldehyde group was developed as a facile protocol to synthesize ortho-alkylated benzaldehydes in moderate to excellent yields (up to 90% yield).To cite this article before page numbers […]Jing-Wen Jia
- UV-mediated anomeric activation Tháng 9 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01184A, PaperNiklas Henrik Fischer, Alicja Klaudia Bałuta, Maciej Tadeusz Szpak, Peter Waaben Thulstrup, Christian Marcus PedersenNonaromatic photoinitiation of trichloroacetimidates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryNiklas Henrik Fischer
- Efficient synthesis of tetrahydroquinolines via selective reduction of quinolines with copper salts and silanes Tháng 9 11, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01085C, CommunicationYulong Zhang, Xinyu Luo, Yushuang ChenWe developed a cost-effective catalytic system using cheap copper salts and silanes to achieve efficient partial hydrogenation of quinolines under mild conditions, yielding diverse 1,2,3,4-tetrahydroquinolines with up to 98% efficiency.To cite this article before page numbers are assigned, use the DOI form of […]Yulong Zhang
- Visible-light-driven domino reactions toward nitrogen-containing heterocycles Tháng 9 11, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01274K, Review ArticleYang Li, Dong Xia, Wen-Chao YangThis review highlights recent advances in visible-light-induced domino reactions for the synthesis of nitrogen-containing heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYang Li
- Tunable regiodivergent C–H alkenylation of 2-arylthiazoles via catalyst control Tháng 9 10, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01310K, PaperGuibin Wan, Cheng Wang, Pengfei Zhou, Yi Tang, Dingyi Xu, Taoyuan Liang, Zongwu Wei, Zhuan ZhangWe have developed a novel and efficient Pd(II)- and Ru(II)-catalyzed switchable C–H alkenylation of 2-arylthiazoles with alkenes, achieving high levels of regio- and stereoselectivity.To cite this article before page numbers are assigned, use […]Guibin Wan
- Annulative coupling of dicoumarols and β-ketosulfoxonium ylides: access to dihydrofuran-fused coumarins Tháng 9 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01305D, PaperRahul Kumar Saini, Satyendra Kumar PandeyA reagent- and catalyst-free cascade annulation of dicoumarols with β-ketosulfoxonium ylides has been developed, offering a scalable and versatile route to bioactive dihydrofuran-fused coumarins through concurrent C–C and C–O bond formation.To cite this article before page numbers are assigned, use the DOI form […]Rahul Kumar Saini
- Advances in the direct transformations of propargylic alcohols and sulphur-containing reagents Tháng 9 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01220A, Review ArticleJiayi Chao, Rumeng Yang, Jiarui Huang, Xi Chen, Xian-Rong Song, Qiang XiaoThis review systematically highlights the advances in the direct transformation of propargylic alcohols with sulphur-containing reagents for the construction of sulphur-containing compounds.To cite this article before page numbers are assigned, use the DOI form of citation […]Jiayi Chao
- Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability Tháng 9 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01223F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Katarzyna Jastrzębska, Agata Szymańska, Tomasz Pawlak, Rafał DolotWe demonstrate the oxathiaphospholane-based synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs with confirmed stereochemistry and enzymatic stability, highlighting their potential for therapeutic applications.To cite this […]Katarzyna Jastrzębska
- Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application in drug modification Tháng 9 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01389E, CommunicationSheng Yu, Yangjian Cheng, Changduo Pan, Jin-Tao YuA photocatalytic radical cascade cyclization of N-acryloylhydrazides with α-bromoketones, α-bromo difluoroacetamides and 2-bromoacetonitrile was developed for the construction of functionalized pyrazolones.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Sheng Yu
- Eco-efficient C–H alkynylation of indoles via mechanochemical ruthenium catalysis Tháng 9 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01198A, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rajaram Maayuri, Vikash Kumar, Sourav Maiti, Parthasarathy GandeepanMechanochemical ruthenium(II)-catalyzed C2-alkynylation of indoles offers a sustainable alternative to solution-phase methods with improved green metrics and broad synthetic scope.To cite this article before page numbers […]Rajaram Maayuri
- Anthracene-isatoic anhydride hybrids for bioconjugation: chromophores with nucleophile dependent response Tháng 9 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01187F, PaperChloe D. Fordyce, Callum J. Robinson, Gabriel E. RudebuschAnthracene-based bioconjugate reagents transform into unique donor–acceptor chromophores when reacted with amines, alcohols or thiols. An 11-residue peptide is selectively labeled at the lysine side chain.To cite this article before page numbers are assigned, use the DOI form of citation […]Chloe D. Fordyce
- DBU-catalysed cascade nucleophilic addition/cyclization to access 7-nitro (ester) imidazo[1,2-a] pyridin-8-amines Tháng 9 8, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01228G, PaperDevendra Nagineni, Abburi Naga Pranathi, Prakash Suman Behera, Manasa Konderpu, Balasubramanian Sridhar, Srinivas KantevariA DBU-catalysed, solvent-free cascade approach is presented for the synthesis of C-7-nitro/ester- and C-8-amine-substituted imidazo[1,2-a]pyridines, from cyanoalkyne precursors and CH-acid via the formation of two new C–C bonds.To cite this article before page numbers are […]Devendra Nagineni
- A computational investigation of aromatic oligoamide foldamer binding to sugar molecules Tháng 9 17, 2025
