RSC – Org. Biomol. Chem. latest articles- Pro-fluorescent ethynylthiophene-based o-nitrobenzyl photolabile protecting group for hydroxamic acid synthesis Tháng 8 5, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00859J, PaperAlbert D. Campbell, Lingaraju Gorla, Ophelia Adjei-Sah, Blaise Williams, Stephen O. Ajagbe, Samer Gozem, Mohammad A. Halim, Carl Jacky Saint-LouisWe report two novel pro-fluorescent, ethynylthiophene-based o-nitrobenzyl photolabile protecting groups that absorb visible light and enable real-time visualization of hydroxamic acid release through a fluorescent nitrosoketone by-product.To cite this […]Albert D. Campbell
- Copper-Catalyzed Amide Synthesis via Transient Amine Activation with Isothiocyanates Tháng 8 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01008J, PaperPinyong Zhong, Kunming Liu, Fu-Min Liao, Bin Huang, Min Yang, Jin-Biao LiuThe development of catalytic amide synthesis strategies without carboxylic acid preactivation remains a formidable challenge. Herein, we report a copper-catalyzed method enabling direct amidation via transient activation of amines using...The content of this RSS Feed (c) The […]Pinyong Zhong
- Recent Advances in Chiral Phosphoric Acids for Asymmetric organocatalysis: A Catalyst Design Perspective Tháng 8 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00719D, Review ArticlePeng-Fei Zhao, Ke Wang, Jia-Xu Wen, Zhang-Mei-Duo Zhu, Hua Zhang, Zi-Heng Wang, Yu-Xin Liao, Chao-Shan Da, Zhi-Hong DuAsymmetric catalysis, as a core technique in organic synthetic chemistry, can efficiently and precisely construct organic compounds with specific stereochemical structures and plays an indispensable role in many fields such...The […]Peng-Fei Zhao
- Synthesis of a Naphthalimide-Functionalized Polymethacrylate: A Turn-on Fluorescent Probe for Sulfinic Acids via Covalent Bond Formation Tháng 8 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00967G, PaperHiroki Tanimoto, Aoi Otsuki, Tomohiro TakenoriA fluorescent naphthalimide azocarboxylate was successfully tethered to a polymethacrylate backbone. The resulting polymeric material exhibits efficient turn-on fluorescence upon sulfinate addition onto the azo moiety forming covalent bonding, with...The content of this RSS Feed (c) The Royal Society of ChemistryHiroki Tanimoto
- Copper catalyzed synthesis of polysubstituted benzimidazoles; an efficient one-pot synthetic approach to N-enylated benzimidazoles Tháng 8 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00418G, PaperFarid Mohaghegh, Farnaz JafarpourWe report the simple synthesis of 1,2-disubstituted benzimidazoles using three versatile building blocks: benzaldehydes, o-phenylenediamines, and phenylpropiolic acid. The protocol facilitates the formation of three C-N bonds and one Csp-Csp...The content of this RSS Feed (c) The Royal Society of ChemistryFarid Mohaghegh
- Gold-Catalyzed Umpolung Sonogashira-Type Coupling of Boronic Acids with Alkynyl Iodine(III) Reagents Tháng 8 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01010A, PaperDan Xiao, Huanjun Zhang, Junxiao Huo, Qin Zhou, Chunyu Han, Jinhua YangA gold-catalyzed C(sp)–C(sp2) cross-coupling reaction between hypervalent iodine(III) reagents and boronic acids has been developed, enabling the efficient synthesis of alkyne derivatives. This methodology features a broad substrate scope, high...The content of this RSS Feed (c) The […]Dan Xiao
- Synthesis of 4-(arylthio)isoquinolin-1(2H)-ones via TBHP-mediated sequential amidation/thioetherification of N-alkylisoquinolinium salts Tháng 8 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01074H, CommunicationJinhui Cai, Chuanquan Chu, Jinhui Peng, Lijuan Jin, Yilin Chen , Dahan Wang, Jinbing Liu, Junyuan Tang, Zi Yang, Mingming YuHere, a simple, efficient, and practical method for the assembly of 4-(arylthio)isoquinolin-1(2H)-ones via TBHP-mediated 1,4-difunctionalization of N-alkylisoquinolinium iodide salts under metal-free conditions is reported. This strategy is highlighted […]Jinhui Cai
- Microwave - Assisted Direct Amidation of Thioesters: A Green Approach Tháng 8 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01014D, PaperHan Cao, Yijun Shi, Peng Yan, Fusheng Bie, Jie MaDirect amidation of thioesters represents a virtually nonclassical route in the synthesis of amides, frequently encountering limitations due to poor compatibility between thioester and amine structures as well as poor...The content of this RSS Feed (c) The Royal Society […]Han Cao
- NaIO₄--Driven Oxidative Dimerization and Cu(I)-Catalyzed Oxidative Decarbonylation: Modular Synthesis of 1,2-Naphthoquinones and Aryl Naphtho[2,b]furans Tháng 8 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01064K, PaperMudassir Ahmad Lone, Gowhar Ahmad Rather, Amir Rashid Tarray, Waseem Iqbal Lone, Showkat RashidSodium metaperiodate-mediated oxidative C–C homocoupling of diverse β-naphthols to 1,2-naphthoquinones in aqueous medium, using 18-crown-6 as an additive, is reported. Subsequent Cu(I) chloride-assisted decarbonylative oxidation of the resulting 1,2-diketones under...The content of this RSS Feed […]Mudassir Ahmad Lone
- Anti-adipogenic Effects of N-Acetyltyramine from Termite-Associated Streptomyces Tháng 8 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01062D, PaperSe Yun Jeong, Mei Tong He, Μihyang Kim, Ki-Hwan Nam, Michael Poulsen, Christine Beemelmanns, Ki Sung Kang, Ki Hyun KimObesity remains a global health challenge, and novel small-molecule modulators of adipogenesis are urgently needed. Here, we investigated the anti-adipogenic potential of metabolites isolated from termite-associated Streptomyces sp. M45. […]Se Yun Jeong
- Dimethyl(methylthio)sulfonium Salt Triggered Dithiocarbamation of Alkenes with CS2 and Amines Tháng 8 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01043H, PaperSha Peng, Cheng-Mei Qi, Li-Mei Duan, Ding Luo, Lu-Can Cheng, Si-Si Tian, Li-Hua Yang, Long-Yong XieIn this work, a straightforward and practical four-component reaction involving alkenes, CS2, amines, and dimethyl(methylthio)sulfonium trifluoromethanesulfonate (DMTSM) is reported. This reaction enables the convenient synthesis of various S-alkyl dithiocarbamates in...The content of this […]Sha Peng
- Efficient Synthesis of Functionalized Alkylidenephthalides, Butenolides, Pyranones, and Isocoumarins via I₂–PPh₃: Synthesis of Thunberginols A and F Tháng 8 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01153A, CommunicationRohitkumar V Abhang, Prathmesh N Bhagwat, Kishor Laxman HandoreA simple and efficient synthesis of functionalized alkylidenephthalides, butenolides, pyranones, and isocoumarins were achieved using I2-PPh3-Et3N reagent combination. The products obtained through this methods act as versatile components in organic...The content of this RSS Feed (c) The Royal Society of […]Rohitkumar V Abhang
- Recent Advances in Radical Addition/Divergent Cyclization of Ynones Tháng 7 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01044F, Review ArticleYan Zhang, Liji Gu, Ruoyang Xu, Weiwei HuanOver the past decade, designing new radical reactions has emergered as an increasingly-powerful strategy to construct complex molecular scaffolds, which usually features divergent predictable reaction outcome, diverse radical precursors, and...The content of this RSS Feed (c) The Royal Society of […]Yan Zhang
- Novel ring-opening rearrangement reactions of N-cyclopropyl-amides: access to N-(2-chloropropyl)amides and 5-methyl-2-oxazolines Tháng 7 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01040C, CommunicationCongcong Wan, Hongling Wang, Xiang ZhangA ring-opening rearrangement reaction of N-cyclopropylamide is shown to occur in the presence of AlCl3. The mechanism is proposed herein involving the “Heine-type” aziridine intermediate and C-Cl or C-O bond...The content of this RSS Feed (c) The Royal Society of ChemistryCongcong Wan
- A nitromethane extrusion reaction for the synthesis of polycyclic benzimidazoheterocycles Tháng 7 31, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00862J, PaperPin-Hui Lin, Kesavan Stalindurai, Si-Yuan Chen, Teau-Jiuan Liou, Ding-Yah YangA metal-free and triphosgene-free annulation of diamines with 4-chloro-3-nitrocoumarins enables efficient synthesis of polycyclic benzimidazoheterocycles via extrusion of nitromethane.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Pin-Hui Lin
- Cu2O-mediated regio- and stereoselective one-pot synthesis of (Z)-3-ylidenephthalides from 2-iodobenzoic acids and terminal alkynes Tháng 7 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00808E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ahmed R. Ali, Longqin HuA series of substituted (Z)-3-ylidenephthalides was synthesized from 2-iodobenzoic acids and various terminal alkynes in the presence of Cu2O in DMF at 100–130 °C.To cite this article before page […]Ahmed R. Ali
- Recent Advances in the Synthesis of Fluorinated Heterocycles and A Close Look on the Recent FDA-Approved Fluorinated Drugs Tháng 7 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00997A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sayan Mukherjee, Ujala Rani, Girish Chandra, Shantanu PalSince the date of inception of artificial drugs and agrochemicals to human society, the presence of a heterocyclic framework in the drug dominates and this […]Sayan Mukherjee
- Pd-NHC-catalyzed N-acylation of sulfoximines with aromatic esters Tháng 7 29, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00981B, CommunicationYuanfang Zhong, Linjie YangNHC-Pd-catalyzed cross-coupling of NH-sulfoximines with aromatic esters; aromatic esters as the 'acylation' sources; avoids using a stoichiometric amount of additives such as B(OH)3, Boc2O, oxidative agents, etc; Wide substrate scope.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Yuanfang Zhong
- Ruthenium-catalyzed C(sp2)−H ortho-heteroarylation of phthalazin-1(2H)-one using thiophenes by cross-dehydrogenative coupling Tháng 7 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01111F, CommunicationAlagumalai Ramkumar, Thirumanavelan GandhiThe cross-dehydrogenative coupling reactions gained supreme importance owing to their synthetic efficiency in accessing simple to complex organic molecules. Herein, we report a Ru(II)-catalyzed directing group-assisted CDC reaction between phthalazin-1(2H)-one...The content of this RSS Feed (c) The Royal Society of ChemistryAlagumalai Ramkumar
- TCCA/PhSH-Mediated regioselective hydroethoxylation and hydromethoxylation of allenamides via a radical process. Tháng 7 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00698H, PaperQingsong Liu, Gele Jiri, Xingyao She, Zhi-Gang Zhao, Xiao-Xiao LiAn efficient TCCA/PhSH-mediated regioselective hydroethoxylation and hydromethoxylation of allenamides via a radical process was developed to create a workable route to γ-oxygenated enamides. This process is highly regioselective, affording (E)-γ-oxygenated...The content of this RSS Feed (c) The Royal Society […]Qingsong Liu
- Pro-fluorescent ethynylthiophene-based o-nitrobenzyl photolabile protecting group for hydroxamic acid synthesis Tháng 8 5, 2025
