RSC – Org. Biomol. Chem. latest articles- Na2S-Catalyzed Dehydrogenative Condensation of 2-Aminobenzyl Alcohols and Ketones: A Synthesis of Quinolines Tháng mười một 6, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01438G, CommunicationLe Anh Nguyen, Thi Thanh Tam Nguyen, Duc Long Le, Quoc Anh Ngo, Thanh Binh NguyenThe transition metal-catalyzed dehydrogenative cyclization of 2-aminobenzyl alcohols with ketones has emerged as a straightforward, simple, and efficient method for synthesizing quinolines. However, this strategy faces numerous limitations. Most notably,...The content of this […]Le Anh Nguyen
- Visible-Light-Induced Radical Trifluoromethylation/Cyclization of Alkynes: Synthesis of CF3-Containing Dioxodibenzothiazepines Tháng mười một 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01520K, CommunicationXiaoyu Chen, Yang Geng, Pan Liu, Zhiyong Wu, Dapeng Zou, Yangjie Wu, Yusheng WuA simple and metal-free photoinduced radical trifluoromethylation/cyclization reaction of alkynes with readily preparable and air-stable trifluoromethyl thianthrenium triflate (TT-CF3 + OTf -) as the trifluoromethyl source has been developed. This...The content of this RSS Feed […]Xiaoyu Chen
- Hypervalent iodine-mediated highly mono- and di-selective etherification of 8-aminoquinolines on the C5 and C6 positions† Tháng mười một 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01378J, CommunicationHongen Qu, Pei Liang, Shi Qiu, Shangqing Xiao, Panpan Huang, Hengshan Wang, Zhonggao Zhou, Liangxian LiuA mild, metal-free and highly regioselective approach for etherification of 8-aminoquinoline scaffolds on their C5 and C6 positions has been developed with hypervalent iodine compounds. The transformation proceeds by the...The content of this […]Hongen Qu
- Electrochemical Synthesis of Hydroxyalkylated Quinoxalines via C-H Functionalization Tháng mười một 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01521A, PaperShuaishuai Dai, Dongping Xu, Lizhen Jin, Yuan-Chao Zha, Wu ZhangAn efficient electrochemical C-H hydroxyalkylation of quinoxalines with aldehydes and ketones has been developed in an undivided cell. A variety of aliphatic and aromatic aldehydes as well as ketones have...The content of this RSS Feed (c) The Royal Society […]Shuaishuai Dai
- H-bonding, not remote participation, explains the influence of remote substituents on stereoselectivity in α-galactosylations Tháng mười một 5, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01495F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kate E. Donaghy, Dionissia A. Pepe, Joseph J. Ruddy, Eoghan M. McGarrigleNon-classical H-bonding of a 4-O-benzoate ortho-hydrogen with the triflate leaving group leads to highly α-selective galactosylation; thus a para-nitrobenzoate outperforms alternatives and […]Kate E. Donaghy
- CuI/TEMPO Mediated Aerobic Oxidative sp3 C-H Functionalization Leading to Pyrrol-2-one Derivatives Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01297J, CommunicationAritra Mondal, Sunanda Mandal, Saikat Khamarui, Souvik Mondal, Bholanath Maity, Tanmoy Dutta, Ayan Hazra, Paramita Das, Suman Ray5-Hydroxy-1H-pyrrol-2-ones represent a very important class of compounds; however, their syntheses rely on the precursors that are quite exotic and commercially unavailable or multistep operations. Though cascade reaction is an...The content […]Aritra Mondal
- Beyond structure and activity: Targeting Class A Carbapenemase with Monocyclic and Bicyclic Boronic Acids to Counter Antimicrobial Resistance Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01703C, CommunicationKunal Dhankhar, Mousumi Hazra, Adwaita S. Nair, Alaa Eddin Alhmeidi Alkhatib, Narayan Chandra Mishra, Saugata HazraBicyclic boronic acids inhibit SME-1 carbapenemase via a unique π–π stacking with His105 and covalent interaction with Ser70. Ledaborbactam shows the strongest inhibition, with the lowest ki and enhanced structural...The content of this […]Kunal Dhankhar
- TBAI-catalyzed C-H bond activation to construct C(sp3)-O bond in water: the synthesis of indole-3-carboxylic-α-esters under metal-free conditions Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01449B, CommunicationXinyuan Zhang, Yufang Sun, Yujie Qu, Shengxing Xie, Fuchun Yang, Chengyu Wang, Jiawen Du, Xiaofeng Zhu, Lingkai Kong, Neng-Fei WangAn environmentally friendly and green transition-metal-free TBAI-catalyzed C-O coupling reaction via C(sp3)-H activation was developed to construct indole-3-carboxylic-α-ester in water. This reaction exhibits a broad substrate scope and good […]Xinyuan Zhang
- Visible light photocatalytic reductive hydroalkylation and deuterium alkylation to access α-Silylated bicyclo[1.1.1]pentanes Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01555C, CommunicationChanglong Zheng, Xin Liu, bin hu, ting Lin, Shi-Peng Luo, Chenguang LiuAs pharmacophores, both bicyclo[1.1.1]pentane(BCPs) sacaffold and silyl substituents have found widespread applications in drug discovery. However, systematic synthetic methods for α-silylated BCPs remain limited. Herein, we report a photocatalytic hydro/deutero-alkylation...The content of this RSS Feed (c) The […]Changlong Zheng
- FeCl3 Catalyzed Synthesis of Fluorene-C-9-linked Furan Hybrids from Biphenyl-linked Conjugated Ene-Yne-Ketones Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01258A, PaperAsadujjaman Nur, Umasish Jana, Abhishek Kar, Kush Mandal, Rajkamal SahooIn this study, we present a novel and efficient synthetic strategy for the construction of fluorene-C-9-tethered furan hybrids in excellent yields, starting from biphenyl-linked conjugated ene-yne-ketones. The reaction proceeds under...The content of this RSS Feed (c) The Royal Society […]Asadujjaman Nur
- Copper-Catalyzed Cross-Coupling Reaction of Epoxides with Allyl Boron Ester Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01598G, PaperXiao-Yu Lu, Jun-Long Zhang, Hao-Yu Dong, Tng-Ting Liu, Xin-Ru Hu, Jin-Tao Tao, Wen-Jing Li, Hui-Tao ZhouHerein, a copper-catalyzed ring-opening cross-coupling reaction of epoxides with allylboronates for the synthesis of γ-alkenyl alcohols is reported. This protocol demonstrates broad functional group compatibility, facilitating the production of secondary...The content of this […]Xiao-Yu Lu
- Tuning artificial oxidase catalysis by cavity modification Tháng mười một 4, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01574J, PaperMingzhe Ren, Mikael BolsEpimerisation of two stereocenters in an articial oxidase changes its kinetic parameters.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryMingzhe Ren
- Reactivity of an aza-dipyrrin and an aza-BODIPY motif bearing two 2-pyridyl units: an emissive NNN binding pocket Tháng mười một 3, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01628B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rosinah Liandrah Gapare, Roberto M. Diaz-Rodriguez, Victoria A. Williams, Mark Atwood, Michael J. Cotnam, James W. Hilborn, Erin R. Johnson, Katherine N. Robertson, Alison ThompsonPro-ligand to aza-BODIPY fluorophore provides turn-on metal sensing via […]Rosinah Liandrah Gapare
- Synthesis of chiral α-alkynyl-α-hydroxyamides by enantioselective alkynylation of α-keto amides Tháng mười một 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01546D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Elena Prieto, Celia Andres, Javier NietoThe α-hydroxyamide moiety is an important structural component in a wide variety of biologically active compounds as well as natural products. Herein, we describe a highly efficient and […]Elena Prieto
- Tandem, copper-catalyzed monodesilylation/CuAAC reactions of 1,4-bis(trimethylsilyl)-1,3-butadiyne and azides for preparation of 4-(TMS-ethynyl)-1,2,3-triazoles Tháng mười một 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01592H, CommunicationYibin Wang, Liyi Feng, Xinying Luo, Liuran Li, Luyong Wu, Yuxue ChenA tandem copper-catalyzed 1,4-bis(trimethylsilyl)-1,3-butadiyne (BTMSBD) monodesilylation/azide CuAAC has been developed for the efficienet syntheis of 1-substituted-4-(TMS-ethynyl)-1,2,3-triazoles. The one-pot, two-step process, which occurs in yields up to 73%, is peformed by...The content of this RSS Feed (c) The […]Yibin Wang
- Development and Applications of Heterogeneous Chiral Bifunctional Alkaloid-Thioureas as Recyclable Organocatalysts Tháng 10 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01582K, PaperAinara Pellicer, Xabier del Corte, Nora Aramburu, Javier Vicario, Patrick Yves Toullec, Aitor MaestroThe development of heterogeneous chiral catalysts is a growing research field, as a recyclable alternative to their homogeneous counterparts. Aiming to identify a general and reliable methodology to access highly...The content of this RSS Feed […]Ainara Pellicer
- Regioselective copper-catalyzed dearomative alkynylation of N-alkyl nicotinate and isoquinoline salts Tháng 10 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01487E, CommunicationJun-Ju Mai, Fei Li, Xiasen Dong, Mingyuan Shi, Xiao-Jing Li, Hua-Dong Xu, Mei-Hua Shen, Chi-Fan ZhuCopper-catalyzed dearomative alkynylation of N-alkyl pyridinium/isoquinolinium salts with terminal alkynes affords 1,6-dearomatized products in high yield and selectivity under mild conditions.To cite this article before page numbers are assigned, use the DOI form […]Jun-Ju Mai
- Correction: Silver-catalyzed synthesis of polyfunctionalized 1,7- and 2,7-benzonaphthyridine scaffolds and access to perlolidine derivatives Tháng 10 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90140E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kirti Vashishtha, Kapil Chahal, Namita Bhoi, Donamol Tomy, Balasubramanian Sridhar, Manjula Alla, Kallu Rajender ReddyTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Kirti Vashishtha
- Ortho-C‒O arylation of aromatic amides with Grignard reagents through Meyers reaction Tháng 10 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01418B, CommunicationYa Wu, Bohao Wang, Yiran Shi, Pei Liu, Jie KongThe ortho-C‒O arylation arylamides is a step-efficiency and straightforward approach for the construction of biphenyl amides but has remained a great challenge. Herein, we report an efficient ortho-C‒O arylation of...The content of this RSS Feed (c) The Royal Society […]Ya Wu
- Heterocyclic Scaffold-Fused Dimethoxy-Dibenzocyclooctynes for Photoactivatable Click Chemistry Tháng 10 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01314C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nils Alfred Larsson, Taegeun Jo, Ulf Bremberg, Stefano Crespi, Luke R Odell, Daniel FürthDibenzocyclooctynes (DBCOs) are widely used in bioorthogonal chemistry for strain-promoted azide–alkyne cycloaddition (SPAAC), but generally lack reactivity toward inverse-electron-demand Diels–Alder […]Nils Alfred Larsson
- Na2S-Catalyzed Dehydrogenative Condensation of 2-Aminobenzyl Alcohols and Ketones: A Synthesis of Quinolines Tháng mười một 6, 2025
