RSC – Org. Biomol. Chem. latest articles- Facile one-pot synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines Tháng 3 3, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01892G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Esra Korkmaz Yurtoğlu, Metin ZoraA straightforward and efficient one-pot protocol for the synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines is reported. When subjected to the reaction with ethylenediamine in refluxing dioxane, bis-α,β-alkynic ketones, i.e. 1,9-diarylnona-2,7-diyne-1,9-diones, afford 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines. […]Esra Korkmaz Yurtoğlu
- Dynamic N-->B Coordination and Anion-selective Turn-On Fluorescence in Oxadiazole-functionalized Organoboranes Tháng 3 3, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01979F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonas Schepper, Andreas Orthaber, Frank PammerA versatile route for the preparation of chemically and electronically diverse Mes2BPh-based boranes (Mes = mesityl, 2,4,6-trimethylphenyl) is presented that allows the conversion of tetrazolyl-rings in a common […]Jonas Schepper
- Tungsten-catalyzed continuous-flow oxidation of sulfides to sulfones with hydrogen peroxide Tháng 3 2, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00125D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ken-ichi Fujita, Yasushi Okamoto, Kazuhiro Matsumoto, Jun-Chul Choi, Yoshihiro KonContinuous-flow oxidation of sulfides to sulfones was achieved with hydrogen peroxide (H2O2) using a column packed with a mixture of oxodiperoxotungstate–2,2’-bipyridine and activated carbon. […]Ken-ichi Fujita
- Multicomponent domino synthesis of 6-azabicyclo[3.2.1]octanes and their cascade ring expansion toward 2-azabicyclo[4.3.1]decanes Tháng 3 2, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01817J, PaperNithya Natarajan, Dhanavardini Mouttousadeappane, Vasuki GnanasambandamComplex azabicyclic scaffolds were synthesized via base-promoted, diastereoselective MDRs using a novel isoindole-based methylene, featuring cascade ring expansion of 6-azabicyclo[3.2.1]octane to 2-azabicyclo[4.3.1]decane derivatives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Nithya Natarajan
- Mn(III)-mediated oxidative cyclisation via C(sp3)–H functionalisation: an efficient strategy for benzo-fused aza-heterocycle synthesis Tháng 2 27, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00041J, CommunicationManpreet Singh, Joung-Wan Lee, Yebin Kim, Dae Young KimAn efficient Mn(III)-mediated strategy has been developed for C(sp3)–H functionalisation of N-aryl cyclic amines with malonates, enabling the synthesis of six- to nine-membered benzo-fused aza-heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Manpreet Singh
- Functionalized porphyrin–fullerene dyads: a pathway to the enhanced performance of perovskite solar cells Tháng 2 27, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00011H, PaperSafi Ullah, Shi-Qi Ye, Zheng-Chun Yin, Guan-Wu WangDyads consisting of a porphyrin with a bulky tert-butyl benzoate group linked to a fullerene cage through a biphenyl spacer were synthesized by the Prato reaction for application in perovskite layers.To cite this article before page numbers are assigned, use the […]Safi Ullah
- A pre-synthetic conjugation methodology of DNA and RNA: Combining on-column conjugation and tandem oligonucleotide synthesis Tháng 2 27, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01870F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jagandeep Saraya, Derek Kyle O'FlahertyAmino modifiers are valuable chemical tools for nucleic acid bioconjugation applications and for probing potential mechanisms relevant to the origins of life. Herein, we describe a streamlined and cost-effective […]Jagandeep Saraya
- Adapting Bower's Intramolecular Aziridination Reaction Allows for a Metal-Free Synthesis of N-H Aziridines Tháng 2 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00025H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Raju Silver, Steven Paul Kelley, Shyam SathyamoorthiInspired by Bower's intramolecular aziridination reaction, we have developed an intermolecular protocol for the preparation of N-H aziridines from olefins. Our reaction is operationally simple and involves […]Raju Silver
- Ynones as Versatile Electrophiles for the Divergent Synthesis of 4H-Chromenes and 1,4-Dihydroquinolines Tháng 2 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00097E, PaperBarla Thirupathi, Gitanjali Mishra, Potnuru Indu, Gitanjali MuduliAn efficient and transition-metal-free strategy for the synthesis of 4H-chromenes and 1,4-dihydroquinolines has been developed using 2-hydroxy/2-amino chalcones and ynones as key reaction partners. The transformation proceeds via a sequential...The content of this RSS Feed (c) The Royal Society of ChemistryBarla Thirupathi
- Substrate-Controlled Divergent Synthesis of Substituted Carbazoles through Cascade Reaction of 2-Alkenylndoles with α,β-Unsaturated Ketones Tháng 2 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00081A, CommunicationShizhou Yang, Mingliang Wang, Hong Jiang, Rui Wang, Yurou Xing, Shuang Luo, Qinlin DingSubstituted carbazoles are valuable N-heterocycles for synthesizing biologically relevant compounds. We established the phosphomolybdic acid/ion liquid-promoted divergent synthesis of substituted carbazoles, leveraging readily available 2-alkenylindoles and unsaturated ketones as starting...The content of this RSS Feed […]Shizhou Yang
- Biocatalytic synthesis of heterobiaryl sulfoxides: A comparative study between Baeyer-Villiger monooxygenases and unspecific peroxygenases Tháng 2 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00171H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pablo Vázquez-Domínguez, Julia Carrión-González, Desirée García-Requena, Marco Fraaije, Nikola Loncar, Rosario Fernández, Katrin Scheibner, Ana Gutierrez, Alejandro Gonzalez-Benjumea, Abel Ros, Gonzalo de GonzaloThe biocatalytic sulfoxidation of heterobiaryl indole-and pyrrole-based sulfides was investigated using […]Pablo Vázquez-Domínguez
- Base-promoted cascade haloamination/β-elimination of alkenyl thianthrenium salts: access to (Z)-β-chloroenamines Tháng 2 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00027D, CommunicationQing-Long Lv, Yue Fan, Yuanbing Qi, Yuzhe Lu, Yinjiang Xue, Ao-Tong Shi, Hongqiang Xia, Dianjun LiA catalyst-free base-promoted cascade chloramination/β-elimination of alkenyl thianthrenium salts with N-chlorosulfonamides to generate (Z)-β-chloro-enamine products due to the π–π interaction has been developed with excellent stereoselectivity.To cite this article before page numbers are […]Qing-Long Lv
- Asymmetric hydrogenation of N-heterocycles for pharmaceutical intermediates: synthetic strategies and theoretical perspectives Tháng 2 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00016A, Review ArticleYiting Pu, Tong Shao, Shaohua Yang, Haneol Cho, Chansoo Kim, Uk Sim, Shuihua Wang, Heechae ChoiThis review summarizes asymmetric hydrogenation strategies for N-heterocycles, integrating DFT-derived mechanistic insights to rationalize stereoselectivity and access key chiral scaffolds found in modern drugs.To cite this article before page numbers are assigned, […]Yiting Pu
- Chromatographic purification of N–H ketimines via suppression of hydrolysis using dried silica gel and Et3N Tháng 2 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00153J, PaperShintaro ShibataHydrolytic decomposition of N–H ketimines during silica gel chromatography is prevented by using vacuum-dried silica and Et3N-containing eluents. This protocol facilitates the reliable purification of various sensitive N–H ketimines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Shintaro Shibata
- Mechanisms of Molecular Oxygen-mediated Selective Hydroxyalkylation and Alkylation of Quinoxalin-2(1H)-ones with Alkylboronic acid: A DFT Investigation Tháng 2 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00112B, Paper Qianmei Hou, Da-Gang ZhouThe mechanisms for the molecular oxygen-mediated selective hydroxyalkylation and alkylation of quinoxalin-2(1H)-ones with alkylboronic acids have been investigated with the M06-2X-D3/ma-def2-SVP method and basis set. The SMD (solvation model based...The content of this RSS Feed (c) The Royal Society of ChemistryQianmei Hou
- Positional isomerization of N-allyl compounds with a practical low-valent cobalt catalyst system Tháng 2 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00051G, CommunicationBranislav Kokić, Ljiljana Koračak, Marina Pećinar, Timothy R. Newhouse, Bogdan Šolaja, Vladimir Ajdačić, Igor M. OpsenicaHerein, we report a practical cobalt-catalyzed method for the (E)-stereoselective synthesis of enamides and N-alkenyl heterocycles via positional isomerization of N-allyl amides and nitrogen heterocycles.To cite this article before page numbers are assigned, […]Branislav Kokić
- Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones Tháng 2 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00063K, PaperHui Zhang, Lin Dong, Chao ZhangAn iridium(III)-catalyzed C-H cyclization between N-arylphthalazinones and 2-chloroacetaldehyde has been developed. This reaction provides efficient access to tetracyclic phthalazine derivatives with broad substrate scope. 2-Chloroacetaldehyde serves as an alkyne equivalent,...The content of this RSS Feed (c) The Royal Society of ChemistryHui Zhang
- Selective functionalization of the 1,6-anhydro moiety and of the double bond of levoglucosenone Tháng 2 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00050A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marco Rizzo, Maria-Jose Calandri, Dmitrii Kurnosov, Chiara Lambruschini, Francesco Raboni, Renata Riva, Luca BanfiVersatile azide 1 was efficiently and selectively synthesized from bio-based LGO and used in various diversity-oriented transformations, affording Ugi products […]Marco Rizzo
- Design of multivalent pharmacological chaperones against Pompe disease via metal-free ligation Tháng 2 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00021E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marc Borie-Guichot, Abdelouahd Oukhrib, My Lan Tran, Cédric-Olivier Turrin, Yves Génisson, Laure Gibot, Stéphanie Ballereau, Cécile Dehoux-BaudoinWe report herein the design of multivalent pharmacological chaperones (PCs), based on d-and l-deoxynojirimycin (DNJ), to treat […]Marc Borie-Guichot
- Correction: Cascade synthesis of 2,3-disubstituted quinazolinones from methyl anthranilates, isocyanides and arylboronic acids via NHC–palladium-catalyzed oxidative coupling reactions Tháng 2 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB90024K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chun Qian, Hao Xu, YuQin ZhangTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryChun Qian
- Facile one-pot synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines Tháng 3 3, 2026
