RSC – Org. Biomol. Chem. latest articles- Construction of functionalized adjacent P(V)–C chiral stereogenic centers via organophosphine-catalyzed asymmetric SN2′ substitution of unsymmetrical phosphine oxides with MBH adducts Tháng 8 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01071C, CommunicationFangfang Zhu, Xiaozhu Wu, De WangConstruction of adjacent P(V)–C dual stereocenters via organophosphine-catalyzed asymmetric SN2′ substitution of unsymmetric phosphine oxides with MBH adducts.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Fangfang Zhu
- Multicomponent strategies for synthesizing naphthyridine derivatives: recent advances and mechanistic insights Tháng 8 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00651A, Review Article Darakshan, Tasneem ParvinThis review highlights advances in one-pot multicomponent synthesis of naphthyridine derivatives, focusing on efficient, atom-economical methods, diverse scaffolds and mechanistic insights fostering innovation in organic synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Darakshan
- Facile access to multi-substituted trifluoromethyl alkenes via dehydroxyfluorination of 3,3-difluoroallyl alcohols Tháng 8 25, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01233C, PaperZhi-Qiang Li, Zaixin Wang, Cheng-Qiang Wang, Jian Zhang, Chao FengThe dehydroxyfluorination of allylic alcohols stands as one of the most direct and effective methods for synthesizing versatile allylic fluorides. However, regioselectivity control in this transformation remains challenging. Herein, we...The content of this RSS Feed (c) The Royal Society […]Zhi-Qiang Li
- Efficient synthesis of trifluoromethyl-containing vicinal chlorohydrins and dichlorides via Mn-catalyzed chlorohydroxylation and dichlorination of α-(trifluoromethyl)styrenes Tháng 8 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01253H, CommunicationJiaqi Huang, Ronghua Zhuge, yuhao Qian, Qingchun Huang, Song CaoEfficient method for the synthesis of trifluoromethyl-containing vicinal chlorohydrins and dichlorides via Mn-catalyzed chlorohydroxylation and dichlorination of α-(trifluoromethyl)styrenes using Na2S2O8 as an oxidant and NaCl as a chlorine source was...The content of this RSS Feed (c) The Royal Society […]Jiaqi Huang
- Organocatalytic modular synthesis of 2-functionalized 2,5-dihydrofuran from γ-hydroxy enal Tháng 8 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01216C, CommunicationTie Lei, Jun Tan, Yifei Zhang, Dengke MaA convenient and modular method for the preparation of diverse 2-O/N/C-functionalized 2,5-dihydrofurans has been developed starting from readily available γ-hydroxy enals via organocatalysis. This reaction features a broad substrate scope,...The content of this RSS Feed (c) The Royal Society of ChemistryTie Lei
- Switchable synthesis of sulfinylated and sulfonylated indoles and benzofurans from o-aminophenyl/o-hydroxyphenyl propargyl alcohols and β-sulfinyl esters Tháng 8 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00969C, CommunicationMing Bian, Cheng-Mei Luo, Li-Na Gao, Tian-Yu Zhang, Yu-Ning Gao, Cun-Feng Song, Hui-Yu Chen, Zhen-Jiang LiuThe cascade reaction of o-aminophenyl/o-hydroxyphenyl propargyl alcohols with β-sulfinyl esters was explored under basic conditions. o-Aminophenyl propargyl alcohols were converted to 3-sulfinyl indoles using KOH, while 3-sulfonyl indoles were obtained...The content of this […]Ming Bian
- A high lipid-soluble probe for ONOO− recognition in the endoplasmic reticulum and imaging of cerebral ischemia-reperfusion injury Tháng 8 21, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01119A, PaperYu-An Feng, Zi-Hao Liu, Wei Du, Ya-Wen Wang, Yu PengA new peroxynitrite (ONOO−) recognition fluorescent probe (SWJT-27) was designed and synthesized for endoplasmic reticulum (ER) stress imaging during the cerebral ischemia-reperfusion injury (CIRI) process.To cite this article before page numbers are assigned, use the DOI form of citation […]Yu-An Feng
- Construction of dansylated (fluorescent) amino acid motifs via C(sp3)-H arylation Tháng 8 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01017A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Debabrata Bhattacharya, Yashika Aggarwal, Subhankar Bodak, Sampurna Pal, Indranil Banerjee, Srinivasarao Arulananda BabuWe described the construction of a library of new examples of dansylated (fluorescent) phenylalanine-type unnatural amino acid scaffolds using the Pd(II)-catalyzed […]Debabrata Bhattacharya
- Interaction Studies by NMR on the Multivalent Interaction between Chondroitin Sulfate E Derivatives and Langerin Receptor Tháng 8 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00845J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria J. García-Jimenez, Sergio Gil, Pedro Dominguez, Laura Roldan, Michel Thepaut, Francisco M. Arrabal, Ignacio Fernández, Franck Fieschi, Javier Rojo, José L. de Paz, Pedro M NietoIn this paper, we presented the 3D […]Maria J. García-Jimenez
- Oxidative Functionalization of Cyclopentane-1,3 Diones: Cell Imaging Studies of Diphenothiazine Derivatives. Tháng 8 20, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01082A, CommunicationSapana Dubey, Pragya Trivedi, Madan Sau, Sukanya Mandal, Shreya Roy, Subhrakanta Rout, Subhojit Das, Gokarneswar Sahoo, Damien Bonne, Tapas DasThis article presents a metal free expedient approach for simultaneous incorporation of heteroatoms and unsaturation in the cyclopentane-1,3-dione via aerial oxidation. We have introduced three distinct methodologies viz. secondary […]Sapana Dubey
- Stereoselective Convergent Total Synthesis of Tonkinelins Tháng 8 20, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01214G, PaperRodney Agustinho Fernandes, Anupama KumariWe report the stereoselective synthesis of (17S,18S,36S)-tonkinelin and its diastereomer (17R,18R,36S)-tonkinelin via a convergent strategy involving the stepwise construction of two key fragments - a chiral ester-derived phosphonium salt and...The content of this RSS Feed (c) The Royal Society of ChemistryRodney Agustinho Fernandes
- Multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing imidazole moiety Tháng 8 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01230A, PaperEkaterina Sergeevna Uvarova , Anton Viktorovich Kutasevich, Tatiana Yu. Koldaeva, Vitaly MityanovA methodology for the synthesis of 2-aminofurans containing an imidazole substituent has been developed. The method is based on a three-component condensation of 2-unsubstituted imidazole N-oxides, arylglyoxals, and 3-ketonitriles. The...The content of this RSS Feed (c) The […]Ekaterina Sergeevna Uvarova
- Visible-light-promoted tandem radical fluoroalkylation/cyclization to access fluoroalkyl-containing chromones/chroman-4-ones Tháng 8 19, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01148E, PaperYuanyuan Ren, Yuxiu Zhou, Xiaona Pan, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yulai HuVarious fluoroalkyl chromones/chroman-4-ones are synthesized through radical cascade fluoroalkylation/cyclization reactions of o-hydroxyaryl enaminones or 2-(allyloxy)benzaldehydes with fluoroalkyl reagents CF3Br and 1,2-dibromotetrafluoroethane.To cite this article before page numbers are assigned, use the DOI form of citation […]Yuanyuan Ren
- Asymmetric total synthesis of (+)-fusariumin and (+)-sporotricale methyl ether: Exploration of Cu(I) catalysed regiodivergent cascade cyclization strategy Tháng 8 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01245G, PaperSamik Nanda, Swagata Das, Anupa KarmakarAsymmetric total synthesis of isocoumarin-based natural product (+)-fusariumin was achieved for the first time through Cu(I) catalysed 6-endo-dig cyclization as a key step. Synthesis of phthalide-based natural product sporotricale methyl...The content of this RSS Feed (c) The Royal Society of ChemistrySamik Nanda
- Silver-mediated intermolecular ortho-trifluoromethoxylation of pyridyl-arenes Tháng 8 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01162K, CommunicationLu Guo, Ruijian Fang, Yun Liu, Zhenbo Zhao, Nuochen Ye, Zhijie Deng, Muhammad Bilal Altaf, Pingping TangThe directing-group enabled ortho-selective C–H trifluoromethoxylation of arenes with silver was developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Lu Guo
- Highly regio- and diastereoselective construction of spirocyclic compounds via palladium-catalyzed [3 + 2] cycloaddition of vinyl methylene cyclic carbonates with pyrrolidinones Tháng 8 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01194A, CommunicationHuizhi Liu, Jiayi Zong, Boxuan Zhang, JiaHao Wang, Guohui Zheng, Miaolin Ke, Fener ChenA palladium-catalyzed [3 + 2] cycloaddition of vinyl methylene cyclic carbonates with pyrrolidinones, which enables the efficient synthesis of various [5,5]-spirolactam derivatives with up to 98% yield and up to >20 : 1 dr, was developed.To cite […]Huizhi Liu
- Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions Tháng 8 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01048A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Selin Yilmaz, Haimei Zhou, Çağrı Özsan, Angelo Frei, Peter O'Brien, William P. UnsworthLarge ring lactam libraries can be made via a conjugate addition/ring expansion cascade and subsequent side-chain and ring elaboration steps.To cite […]Selin Yilmaz
- Synthesis and physicochemical evaluation of phosphorus(III) and phosphorus(V) substituted benzoxaboroles Tháng 8 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01146A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elisa Ospanow, Mirele Barsoum, David L JakemanThis study presents a one-pot synthesis of phosphorus(III) benzoxaboroles using hypophosphorous acid to yield H-phosphinates. These H-phosphinates, together with their phosphonate congeners, were systematically evaluated for their […]Elisa Ospanow
- Rapid Construction of Furan-linked Bisheterocycles via Palladium-catalyzed Domino Heck/Cross-coupling Reaction Tháng 8 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01081K, PaperDu Wang, Zhilong Yin, Xueli Feng, Huixuan Zhu, Fan Gao, Jiaxin Li, Jingli Zhang, Ye YuanA palladium-catalyzed domino Heck/cross-coupling reaction of alkene-tethered aryl iodides with β-chloroenones is reported. This reaction enables the formation of one C-O bond, two C-C bonds to construct bisheterocycles in a...The content of this […]Du Wang
- O-Aryl carbamates of 2-substituted piperidines: anionic Fries rearrangement and kinetic resolution by lithiation Tháng 8 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01049G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Marra, Fabrizio Morelli, Federica De Nardi, Emanuele Priola, Iain Coldham, Marco BlangettiA chemodivergent organolithium-mediated protocol to promote anionic Fries rearrangement (AoF) or kinetic resolution (KR) processes starting from O-aryl carbamates of 2-substituted […]Francesco Marra
- Construction of functionalized adjacent P(V)–C chiral stereogenic centers via organophosphine-catalyzed asymmetric SN2′ substitution of unsymmetrical phosphine oxides with MBH adducts Tháng 8 25, 2025
