RSC – Org. Biomol. Chem. latest articles- Transition-metal-free K2S2O8-promoted oxidative C-C triple bond cleavage and esterification leading to α-keto esters Tháng 6 25, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00892A, PaperJin-Xin Lan, Yu Shu, Yang Zhou, Liu-Yu Shen, Fei Meng, Wen-Chao YangA sustainable method for converting alkynes into α-keto esters is reported through K2S2O8-promoted oxidative C-C triple bond cleavage and esterification. This approach avoids transition metal catalysis, photocatalyst, and pure oxygen...The content of this RSS Feed (c) The […]Jin-Xin Lan
- Ni-Catalyzed Intramolecular Cyclization of 2-Cyanoaniline B-H Adducts towards 2,3-Dihydroquinolin-4(1H)-ones Tháng 6 25, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00778J, CommunicationMin Yang, Xuanfeng Li, Jian Xiao, Tingxi Lai, Minghui Xu, Bin Chen, Hai-Liang Ni, Bi-Qin Wang, Ping Hu, Peng CaoThe Ni-catalyzed reductive cyclization of 2-cyanoaniline B-H adducts is unprecedentedly presented. A novel class of quinolin-4-ones containing a quaternary carbon center were synthesized in moderate to good yields. With […]Min Yang
- One-pot Synthesis of trans-2,3-Diaminoindolines through 2,3-Diamination of Electrophilic Indolines Tháng 6 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00877H, CommunicationYuito Kobori, Keisuke Tokushige, Takumi AbeDespite recent advances in the synthesis of 2,3-diaminoindole derivatives, construction of 2,3-diaminoindolines, which have different diamine moieties, has yet to be achieved. In this work, we introduce a concise one-pot...The content of this RSS Feed (c) The Royal Society of ChemistryYuito Kobori
- First Stereoselective Approach for Structure Revision of Nagiol and Syntheses of 2,3-Dihydroxyferruginol and Ferruginol Tháng 6 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00946D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sravya Surendran, Arathi Ramachandran, Rajendar GoretiWe report the first enantioselective total synthesis of nagiol, accompanied by a revision of its previously proposed structure. This synthetic strategy has been successfully extended to the total […]Sravya Surendran
- Activating Human 15-Lipoxygenase-1 Beyond Flatland: Discovery of Non-Aromatic Modulators Tháng 6 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00820D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marina Somaraki, Ioannis Zachilas, Elvira Tsapinou, Georgianna Boulkou, Tamsyn Montagnon, Georgios Vassilikogiannakis, Nikolaos EleftheriadisModulation of enzyme activity by small molecules is a powerful therapeutic strategy. While human 15-lipoxygenase-1 inhibitors are well-studied, activators have […]Marina Somaraki
- Microwave assisted Cobalt(III)-catalysed C-H aminocarbonylation reactions with isocyanates for the synthesis of thiophenecarboxamides Tháng 6 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00781J, PaperBorja Taboada-Seras, Carlos Santiago, Eider Sustatxa, Asier Carral-Menoyo, Nuria Sotomayor, Esther LeteA mild and efficient cobalt(III)-catalysed C-H aminocarbonylation procedure for thiophenes and benzo[b]thiophenes under MW assisted conditions has been developed. Site selectivity is controlled by the use of pyridine and pyrimidine...The content of this RSS Feed (c) The […]Borja Taboada-Seras
- Antiadhesive glycoconjugate metal complexes targeting pathogens Pseudomonas aeruginosa and Candida albicans Tháng 6 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00970G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Karolina Wojtczak, Emilie Gillon, Diana Bura , Karen Richmond, Megan Joyce, Emma Caraher, Keela Kessie, Trinidad Velasco-Torrijos, Cristina Trujillo, Anne Imberty, Kevin Kavanagh, Gordon Cooke, Joseph P ByrneGlycoconjugates are known to interact with […]Karolina Wojtczak
- Fluorinated cyclopropanes for 2-heterosubstituted electron-rich indolizine synthesis Tháng 6 24, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00628G, PaperAngelina Yu. Bobrova, Maxim A. Novikov, Julia V. Burykina, Konstantin P. Trainov, Yury V. TomilovA diverse series of two- or three-component-derived 2-F,N,S,O-subtituted indolizines was prepared as a new product type for fluorocyclopropane chemistry.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Angelina Yu. Bobrova
- K2S2O8-promoted one-pot synthesis of N-substituted quinazolinones via tandem annulation using DMSO and terminal alkynes Tháng 6 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00898K, PaperAjay Uppuluru, Sumit Kumar, prithivirajan babu, Anilkumar Kommoju, Kishor Padala, Annamalai PratheepkumarA three-component reaction involving 2-aminobenzamide, phenylacetylene, and DMSO in the presence of K₂S₂O₈ as an oxidant has been developed to access a wide range of N-substituted quinazolinones. In this methodology,...The content of this RSS Feed (c) The […]Ajay Uppuluru
- Electrochemical trifluoromethylation of alkenyl oximes for the synthesis of isoxazolines and cyclic nitrones via radical annulation Tháng 6 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00694E, PaperJiangfei Chen, Minghao Yan, Min-Qi Wu, Xin-Yu Jiang, Jue-Ru Wan, Zhiqiang Ren, Ming Yuan, Kuo Zhou, Chengjin Shi, Sheng-Rong GuoA highly efficient and environmentally friendly approcah to access fluorine-containing isoxazoline and cyclic nitrone derivatives without any oxidants addition is reported. In this electrochemical system, Sodium trifluoromethanesulfonate (CF3SO2Na) serves […]Jiangfei Chen
- Suppression of Rapid Deactivation of Catalytic Tetrapeptides in the Asymmetric Michael Addition of Aldehydes to Nitroolefins by Supporting Them on Polymers Tháng 6 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00667H, PaperMeng Yuan, Yang-Xin Liu, Tie-Ying Ding, Ze-Xuan Zhang, Tian-Rui Lian, Peng-Fei Zhao, Zhi-Hong Du, Chao-Shan DaThe limited efficiency of N-primary amine-based peptides as organocatalysts for the asymmetric Michael addition of aldehydes to nitroolefins is largely attributed to their rapid deactivation, a phenomenon whose underlying mechanism...The content of this […]Meng Yuan
- Triple role of boronic acid as a catalyst in the alkylation of quinoline to functionalized tetrahydroquinoline Tháng 6 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00895F, PaperSiddhartha Kumar Senapati, Asish Borah, Swagata Hazarika, Animesh DasThe triple role of arylboronic acid as a catalyst in the alkylation of quinoline to N-substituted tetrahydroquinoline with diaryl motif at the C6-position has been developed. This reaction involved the...The content of this RSS Feed (c) The Royal Society of […]Siddhartha Kumar Senapati
- Stereoselective Synthesis of Pyrano[2,3-c]pyrazolone Derivatives via Light-induced NHC Catalyzed [4+2] Annulations Tháng 6 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00586H, PaperSiyan Miao, Xian Li, Yao Chen, Chenxia Yu, Jiaomei Wang, Changsheng Yao, Kai ZhangHerein, chiral pyrano[2,3-c]pyrazolone derivatives bearing vicinal tertiary and quaternary carbon stereocenters have been synthesized via light-induced N-heterocyclic carbene (NHC) catalyzed asymmetric [4+2] cycloaddition of 4-arylidenylpyrazolones and α-diazoketones in moderate to...The content of this RSS Feed […]Siyan Miao
- Organic electrochemical reactions of inorganic compounds Tháng 6 22, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00777A, Review ArticleJiangfei Chen, Juyue Yang, Dayun Huang, Ming YuanThis review discusses the electrochemical applications of inorganic compounds as starting materials in organic synthesis (2013–2024). In some cases, additional electrolytes are unnecessary due to the presence of inorganic substrates.To cite this article before page numbers are assigned, use the […]Jiangfei Chen
- Titanium-catalyzed Radical-type Deuteriodeboronation of Arylboronates Tháng 6 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00837A, CommunicationZhihui Wang, Biao Ma, Li Haocong, Wang Yiru, Li ZhanyuDeuterated aromatic compounds have extensive applications in organic synthesis and the pharmaceutical industry. Nevertheless, the development of cost-effective transition metal catalysis remains pressing. In this study, we present an unprecedented...The content of this RSS Feed (c) The Royal Society […]Zhihui Wang
- Ruthenium catalysed isomerisation-methylenation of allyl alcohols with methanol: A one-pot synthesis of substituted pyridines Tháng 6 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00881F, PaperPriyabrata Biswal, Sanu Siyad Pullarat, Shaikh Samser, Basava P. R. Aradhyula, Vadapalli Chandrasekhar, Krishnan VenkatasubbaiahA simple bench-stable ruthenium-complex facilitates the synthesis of tetra-substituted pyridines in one-pot via isomerisation-methylenation of allyl alcohol using methanol as a C1 source. This methodology is applicable to a broad...The content of this RSS […]Priyabrata Biswal
- Dual Photoredox-/Palladium-Catalyzed Three-component Reaction for Synthesis of Trifluoromethylated allylic alcohols Tháng 6 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00926J, CommunicationXiao-Lin Wang, Kavuri Rupa, Sheng-Cai Zheng, Xiaoming ZhaoIn the presence of dual photoredox/palladium catalysis, an effective three-component allylic reaction using simple and easily obtained cyclic vinyl carbonate, olefin and CF3SO2Na was documented for synthesis of trifluoromethylated allylic...The content of this RSS Feed (c) The Royal Society of ChemistryXiao-Lin Wang
- Synthesis and Biological Evaluation of Naphthoquinone-Fused Pyrrole and Imidazopyridinedione Heterocycles Tháng 6 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00564G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Raju Dey, Rabindra Nath Sana, Sudipta Chakraborty, Vageesh M, Soumen Adak, Tanurima Bhaumik, Susanta Kumar MannaWe have developed an efficient and easy synthetic route to obtain naphthoquinone fused pyrrole derivatives (up to 93% […]Raju Dey
- An efficient, safe, and scalable method for the preparation of D- and L-penicillamines Tháng 6 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00865D, PaperCharan Kumar G, S. Anusooya, Jashuva V. P. Katuri, Mariappan Arumugam, Govinda Rajulu G, Sambasivam Ganesh, C. S. KarthikThe present work describes a simple, efficient and scalable route for the synthesis of D- and L-penicillamines from commercially available ethyl isocyanoacetate.To cite this article before page numbers are assigned, […]Charan Kumar G
- Specific phosphorylation patterns control the interplay between aggregation and condensation of Tau-R4 peptides Tháng 6 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00885A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shachar Guy Bressler, Dana Grunhaus, Amit Aviram, Stefan G. D. Rüdiger, Mattan Hurevich, Assaf FriedlerOur study shows, by using synthetic multiphosphorylated peptide libraries that specific phosphorylation patterns govern the decision between aggregation and […]Shachar Guy Bressler
- Transition-metal-free K2S2O8-promoted oxidative C-C triple bond cleavage and esterification leading to α-keto esters Tháng 6 25, 2025
