RSC – Org. Chem. Front. latest articles- Rh(I)-Catalyzed [4+2]-annulation of furan-fused cyclobutanones with alkynes and synthetic applications Tháng 5 7, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00064E, Research ArticleXinfang Xu, Lixin Qian, Jingjing Huang, Kemiao Hong, Xinyu Jiang, Mengting Liu, Chen Gang, Dorota GrykoFully-substituted aromatic skeletons have received increasing interest from the synthetic chemistry, pharmaceutical and material sciences. However, diversity-oriented construction of these molecules remains challenging due to the lack of effective synthetic...The content of […]Xinfang Xu
- Copper-Catalyzed Cloke-Wilson Rearrangement for the Synthesis of Dihydrofurans Containing Tetrasubstituted Carbon Atoms Tháng 5 7, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00401B, Research ArticleQinqin Cui, Shouang Lan, Xiang Lei, Chao Xu, Chunyun Jiang, Lili Zhao, Liyuan Zhou, Jinggong Liu, Cheng-Zhi Gu, Shuang Yang, Xinqiang FangThe Cloke-Wilson rearrangement is a well-established method for synthesizing dihydrofurans, but it primarily results in dihydrofurans lacking tetrasubstituted stereocenters. In this study, we introduce a copper-catalyzed […]Qinqin Cui
- Cu-Catalyzed Regiodivergent and Stereoselective Silylation of 2,3-Disubstituted 1,3-Dienes Tháng 5 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00512D, Research ArticlePinglu Zhang, Ziwei Luo, Hao Zeng, Junyang Cen, Ze Li, Guoqiao LaiRegiodivergent silylation of conjugated dienes represents an elegant and straight forward approach to access diverse organosilicon compounds. While the silylation of 1- or 2- substituted conjugated dienes has been well...The content of this RSS Feed (c) […]Pinglu Zhang
- Palladium-catalyzed site-selective C−H polyfluoroarylation of arenes via aryl thianthrenium salts Tháng 5 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00473J, Research ArticleChen Chen, Jin-Ping Liu, Xin-Yu Hu, Zi-Yi Wang, Xiao-Xu Zhang, Jia-Hui Song, Yan-Ping Zhu, Chunjie Ni, Bolin ZhuThis study introduces a novel method for the selective formal C−H/C−H cross-coupling of arenes with polyfluoroarenes via aryl thianthrenium salts under palladium catalysis, resulting in the production of a range...The […]Chen Chen
- Catalyst-Controlled 5-exo and 6-endo Cyclization: Regiodivergent Access to Indolinones and Dihydroquinolinones Tháng 5 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00516G, Research ArticleXianzhou Zheng, Youzhi Xu, Genping Huang, Weiming YuanFive- and six-membered benzo-fused lactams are important and prevalent scaffolds in many natural products and biologically active compounds. In spite of considerable advances toward their synthesis, the intramolecular alkene functionalization...The content of this RSS Feed (c) The Royal Society of […]Xianzhou Zheng
- Cs2AgBiBr6-Photocatalytic Trifluoromethylation: Insights in Structural Changes and Applications in Drug Modification Tháng 5 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02237H, Research ArticleDebin Yang, Yalin Guo, Yuanzhe Li, Bo Hu, Bing Yu, Qingchuan DuanThe development of new drugs involves complex processes of molecular design, drug screening, and clinical validation, where structural modifications play a crucial role. The trifluoromethyl (CF3) group is significant in...The content of this RSS Feed (c) […]Debin Yang
- Access to ester-substituted γ-butyrolactones via photocatalyzed alkoxycarbonylation/lactonization of alkenoic acids Tháng 5 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00520E, Research ArticleYuping Xiong, Ping Liang, Wenlin Xie, Jian-Qiang Chen, Jie WuWe reported a versatile and concise method to realize the photoredox-induced alkoxycarbonylative lactonization of alkenoic acids for the construction of ester-substituted γ-butyrolactones. This method achieves a multistep cascade reaction by...The content of this RSS Feed (c) The Royal […]Yuping Xiong
- Design and Synthetic Utility of New HAT Organocatalysts Derived from Commercially Available Diamines Tháng 5 5, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00509D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jingwen Jia, Terumasa Kato, Keiji MaruokaA series of hydrogen-atom transfer (HAT) organocatalysts were conveniently prepared from commercially available diamine compounds, and their utility in photoinduced HAT catalysis ability was investigated. The combination […]Jingwen Jia
- Fluorine-containing macrocyclic peptides and peptidomimetics Tháng 5 5, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00219B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Neshat Rozatian, Stefan RoesnerThis review covers recent advances in the synthesis and application of fluorine-containing macrocyclic peptides and peptidomimetics.To cite this article before page numbers are assigned, use the DOI form of […]Neshat Rozatian
- Synergistic catalytic allenylic alkylation for stereodivergent construction of allenes bearing 1,3-axial central chirality Tháng 5 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00467E, Research ArticleMin Chen, Yuzhen Li, Jun He, Lili Lin, Liang-Wen Feng, Xiaohua LiuA highly efficient asymmetric allenylic alkylation for the construction of allenes bearing allenyl axial and central chirality through synergistic Ni/Pd catalysis has been developed. This catalytic protocol operates smoothly under...The content of this RSS Feed (c) […]Min Chen
- Mechanistic insights into ligand-controlled diastereoselectivity in iridium-catalyzed stereoselective coupling of allylic ethers and alkynes: a DFT perspective Tháng 5 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00343A, Research ArticleManzhu Zhao, Lihan Zhu, Qian Zhang, Jingping ZhangRegulating the diastereoselectivity of a reaction is highly attractive but extremely challenging, density functional theory computations are employed to investigate an iridium-catalyzed ligand-controlled diastereoselectivity switch propargylic C−H functionalization. Energetically most...The content of this RSS Feed (c) The Royal Society of […]Manzhu Zhao
- Beyond HAT: harnessing TBADT for photocatalyzed Giese-type C(sp3)–C(sp3) bond formation through reductive decarboxylation Tháng 5 2, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00399G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matteo Leone, Dalila Arnaldi, Maurizio FagnoniOur study reports a novel application of TBADT as a valid reductant, overcoming the intrinsic limitations of hydrogen atom transfer. Our methodology was applied for the generation […]Matteo Leone
- Enantioselective construction of cycloalkyl amines via nickel-catalysed alkene desymmetrization Tháng 4 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00590F, Research ArticleLudi Li, Bo Chen, Wenxu Cao, G. V. Surendra Babu, Weike Liao, Pengli Zhang, Guoqin XiaEnantioselective construction of cycloalkyl amines with two adjacent chiral centers via transannular directed, NiH-catalysed cycloalkene desymmetric hydroalkylation.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Ludi Li
- Tetraphenylethylene or naphthalimide-functionalized dendritic carbazole AIEgens: self-assembly visualization, three disparate force-triggered fluorescence responses, and advanced anticounterfeiting applications Tháng 4 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00393H, Research ArticleYijie Zou, Zhao Chen, Fei Zhao, Ya Yin, Kaixin He, Xingru Liang, Hai-feng He, Zhijian Li, Sheng Hua LiuSix dendritic AIEgens exhibiting self-assembly and three distinct types of force-responsive emissive features are developed, and two advanced information security systems are constructed.To cite this article before page numbers […]Yijie Zou
- Copper-catalyzed aryl ortho-C–H thiolation of aldehydes via a transient directing group strategy Tháng 4 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00472A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingshun Mei, Dongsheng Yi, Fanyi Meng, Junhao Tang, Yanghui ZhangThe Cu-catalyzed C–H thiolation reaction of aromatic aldehydes has been developed via a transient directing group strategy.To cite this article before page numbers […]Mingshun Mei
- Synthesis of 8-membered trifluoromethyl benzoxazocines via a Pd-catalyzed ring-expansion reaction of trifluoromethyl benzoxazinones with 2-methylidenetrimethylene carbonate and mechanistic investigations Tháng 4 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02076F, Research ArticleBo Yang, Peng-Fei Sun, Xue Ma, Zhouyang Long, Li-Ming ZhaoA Pd-catalyzed ring-expansion reaction of trifluoromethyl benzoxazinones with 2-methylidenetrimethylene carbonate to access 8-membered trifluoromethyl benzoxazocines is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Bo Yang
- Multicomponent synthesis of unsymmetrical 1,2-diamines via photo-induced carbonyl alkylative amination Tháng 4 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00479A, Research ArticleZhuohua Li, Wenjie Yan, Xiao Zhou, Chao Yang, Lin Guo, Wujiong XiaA photo-induced carbonyl alkylative amination for the synthesis of alkyl/aryl-substituted unsymmetrical 1,2-diamines is herein reported under catalyst- and base-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Zhuohua Li
- Enantioselective and diastereodivergent construction of oxindole–pyrazolone conjugates bearing an alkenyl substituted quaternary chlorinated stereogenic centre Tháng 4 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00499C, Research ArticleJiapei Chen, Xusheng Duan, Mengyuan Wu, Guishun Bai, Jianwei Chen, Xuanrong Sun, Jean Rodriguez, Damien Bonne, Hong Wang, Xiaoze BaoAn enantioselective and diastereodivergent construction of an oxindole and pyrazolone scaffold bearing an alkenyl-substituted quaternary chlorinated stereogenic centre is developed.To cite this article before page numbers are assigned, […]Jiapei Chen
- 1,2 Wagner-Meerwein Shift in Aza-Nazarov Cyclization: Bi(III)-Catalyzed Substrate-Dependent Divergent Synthesis of Highly Substituted Pyrroles and Indenes Tháng 4 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00168D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Deepak Datta Gaonkar, Shon Gangai, Krishna Appasaheb Mhaske, Rishikesh NarayanNazarov reaction and its variants such as Aza-Nazarov and Iso-Nazarov cyclizations are versatile methods for the synthesis of five-membered ring systems including pyrroles […]Deepak Datta Gaonkar
- Regioselective C–H alkynylation with haloalkynes enabled by nitrogen functionalities via Rh catalysis Tháng 4 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00578G, Research ArticleQiaoya Zhang, Bifu Liu, Ci Chen, Yinling Li, Kejun Feng, Sheng Hu, Yang Gao, Yanping Huo, Qian Chen, Xianwei LiHerein, we developed a transformable nitrogen functionality enabled regioselective C–H alkynylation cascade with aliphatic haloalkynes, furnishing alkynes and heterocycles, which thus facilitated concise delivery of CB2 receptor agonist, […]Qiaoya Zhang
- Rh(I)-Catalyzed [4+2]-annulation of furan-fused cyclobutanones with alkynes and synthetic applications Tháng 5 7, 2025
