RSC – Org. Chem. Front. latest articles- Structurally Divergent Reactivity of 2,2-Disubstituted Azetidines – Mechanistic Insights and Stereochemical Implications of Amide Coupling and Ring Expansion to 5,6-dihydro-4H-1,3-oxazines Tháng 8 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00804B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aditya K. Sahay, Callum S Begg, Xiurong Zhang, James A Bull, Alan C SpiveyAzetidines have gained traction in drug discovery for their ability to introduce conformational constraint and modulate physiochemical properties. Strategies […]Aditya K. Sahay
- Photocatalyzed Defluorinative Allylsulfonylation of Alkynes to Access gem-Difluorinated Sulfonyl-1,4-Dienes Tháng 8 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01008J, Research ArticleMeng-Dan Wang, Hua-Hua Wang, Lin-Xi Xiao, Xing-Guo Zhang, Hai-Yong TuA photocatalyzed three-component gem-difluoroallylsulfonylation of alkynes with trifluoromethyl alkenes and sodium sulfinates via selective C-F bond activation has been described. This metal-free allylsulfonylation provides an efficient strategy for the stereospecific...The content of this RSS Feed (c) The Royal […]Meng-Dan Wang
- Clean and Economic Synthesis of N-sulfonyl Isothioureas from Isocyanides, Sulfonamides and Disulfides Tháng 8 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00867K, Research ArticleChangping Xun, Zhibin Nong, Kun Hu, Wenfeng Lv, Jiajun Zhao, Ziqiong Yin, Jialu Lv, Feng Jiang, Qing-Wen GuiAn electrochemical three-component reaction involving isocyanides, sulfonamides and disulfides was developed, using nBu4NI as a redox catalyst and electrolyte. A rare of N-to-N [1,3]-H shift was observed in this transformation....The […]Changping Xun
- Core modified N-confused pentaphyrin variants with adaptive (anti)aromaticity Tháng 8 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01088H, Research ArticleHarapriya Rath, Manik Jana, Gunasekaran Velmurugan, Sumit Sahoo, Peter CombaRetrosynthetically designed and syntheses of three unprecedented core modified N-confused pentaphyrins(sapphyrin) possessing E-ethylene bithiophene moiety with tunable Hückel (anti)aromaticity is reported. The solution-state spectroscopic analyses reveal the sustained E-conformation for...The content of this RSS Feed (c) The Royal […]Harapriya Rath
- Recent Advances in C(sp³)–H Functionalization via Molecular Electrocatalysis Tháng 8 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01036E, Review ArticleXiao-Li Lai, Ying-Kai Lai, Peng Xiong, Hai-Chao XuThe selective functionalization of inert C(sp³)–H bonds remains a central challenge in modern organic synthesis. Molecular electrocatalysis provides a sustainable platform for C(sp³)–H activation by enabling catalyst-controlled electron transfer or...The content of this RSS Feed (c) The Royal Society of […]Xiao-Li Lai
- Harnessing the synergistic power of light and electricity: An emerging frontier in catalytic heterocycle synthesis Tháng 8 26, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01097G, HighlightYanchen Chen, Binbin HuangThe strategic integration of photochemistry and electrochemistry in organic synthesis has opened new avenues for catalytic heterocycle synthesis. This Highlight provides a comprehensive overview of photoelectrocatalytic heterocycle forming strategies, discussing...The content of this RSS Feed (c) The Royal Society of ChemistryYanchen Chen
- Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls Tháng 8 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00816F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lucía Sánchez-Jiménez, Adrián Gargantiel, Manuel A. Fernández-Rodríguez, Patricia García-GarcíaDivergent gold-catalyzed cycloisomerizations of o-cyclopropylidenemethyl-o′-alkynylbiaryls give access to two distinct polycyclic scaffolds containing a tricyclic bridgehead carbon center, with selectivity controlled by temperature.To cite […]Lucía Sánchez-Jiménez
- Pd-Catalyzed Hydroesterification of Vinyl Cyclopropanes with Aryl Formates Tháng 8 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00634A, Research ArticleJunhua Li, Chunyin Li, Jing Li, Zhanwei Wang, Fengyin Wang, Yian ShiA Pd-catalyzed hydroesterification of vinyl cyclopropanes with aryl formates is described. A wide variety of cyclopropane-containing or ring-opening carboxylic esters can be obtained in good yields under mild reaction conditions....The content of this RSS Feed (c) […]Junhua Li
- Light-Promoted Cobalt-Catalyzed Radical Markovnikov Hydrothiolation of Alkenes with N-Arylsulfenyl Phthalimides Tháng 8 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01020A, Research ArticleXiang-Rui Li, Rong-Jin Zhang, Ting-Ting Miao, Yonghong Xiao, Kun-Quan Chen, Jian-Ji ZhongIn recent years, transition-metal hydride catalysis has emerged as a powerful strategy for radical Markovnikov hydrothiolation of alkenes, providing efficient access to branched thioethers. However, this approach remains underexplored, with...The content of this RSS Feed (c) […]Xiang-Rui Li
- Diastereo- and enantioselective construction of 1,4-nonadjacent alkyne-tethered products through CuI-promoted deprotonation and addition of terminal alkynes Tháng 8 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00995B, Research ArticleJiale Zheng, Wan-Hong Yuan, Han-Wen Zheng, Wei Du, Ying-Chun ChenWhile catalytic asymmetric alkynylation reaction has been extensively studied, existing examples predominantly focus on the construction of stereogenic center at the addition site. Here we disclose a chiral CuI complex-catalysed...The content of this RSS Feed (c) The Royal […]Jiale Zheng
- Radical conjugate addition to 2-substituted chromones via an electron donor–acceptor complex Tháng 8 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00933B, Research ArticleYunbi Koh, GaYeon Yoo, Jinsung Tae, Sanghee Lee, Ansoo LeePhotocatalyst-free radical conjugate addition to chromones via EDA complexes yields immunosuppressive 2,2-disubstituted chroman-4-ones under mild conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Yunbi Koh
- Conformation-tunable hydrogen-bonded calix[2]aramide macrocycles: bridging aggregation-induced emission and charge-transfer host-guest chemistry Tháng 8 20, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00987A, Research ArticleZiying Lu, Xiongrui Ai, Yingxiao Mu, Mingbing Lian, Yanping Huo, Zecong YeTwo novel hydrogen-bonded calix[2]aramide (C[2]A) macrocycles were successfully synthesized by linking crescent aramide tri-mers via methylene bridges. The macrocycles exhibited aggregation-induced emission and clusterization-triggered emission phe-nomenon, enhanced solid-state luminescence efficiency...The content of this RSS Feed (c) […]Ziying Lu
- Synergistic Ni/Co catalysis in C(sp2)–C(sp3) reductive coupling: a DFT study Tháng 8 19, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00975H, Research ArticleJunjie Liu, Fengjiao Xiao, Weichi Chen, Abing DuanOur study uncovers the detailed mechanism behind the reductive coupling of aryl halides and alkyls using a Ni/Co dual catalysis system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Junjie Liu
- The stereochemistry of substitution at S(VI) Tháng 8 19, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01043H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Oliver L. Symes, James A. BullThis review examines the mechanism and stereochemical outcome of substitution reactions at chiral S(VI) electrophiles.To cite this article before page numbers are assigned, use the DOI form […]Oliver L. Symes
- Bypassing the Abnormal Chichibabin Reaction Dead-End Provides a Biomimetic Access to Pre-Haouamine Tháng 8 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01111F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Axel Leblond, Erick Caique Costa, Karine Leblanc, Edmond Gravel, Jean-François Gallard, Mehdi Beniddir, Erwan PouponHaouamines are highly constrained marine alkaloids possessing a unique in nature skeleton. The high degree of complexity of […]Axel Leblond
- Cooperative N-heterocyclic carbene/photocatalysis: visible-light-promoted tandem α-sp3 C–H activation and reductive N-alkylation of tetrahydroisoquinoline Tháng 8 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01032B, Research ArticleKarthiyayini Gnanaoli, Deepan Babu Rajkumar, C. Uma MaheswariVisible-light mediated, NHC-catalyzed tandem α-sp3 C–H activation & reductive N-alkylation of tetrahydroisoquinoline was reported. The reaction proceeds via deprotonated o-hydroxybenzaldehydes as self-photocatalyst in presence oxygen and sunlight.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Karthiyayini Gnanaoli
- Nickel-catalyzed [4 + 1] sila-cycloaddition: a divergent synthesis of silacarbocycles from trichlorosilanes Tháng 8 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01018G, Research ArticleLiangliang Qi, Peng-Fei Xu, Yu-Ke Wu, Xiaobo Pang, Xing-Zhong ShuCyclic chlorosilane transformations present a valuable opportunity for the divergent synthesis of silacarbocycles, but their low availability has hindered this potential.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Liangliang Qi
- Manipulating stereo-communication in binaphthol-bridged α- and β-cyclodextrins to develop β-selective chiroptical pH switching and anion sensing in water Tháng 8 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00910C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Giovanni Preda, Sonia La Cognata, Laura Pedraza-González, Laurine Carlier, Maxime Kolb, Gennaro Pescitelli, Valeria Amendola, Dominique Armspach, Dario PasiniThe unfavourable stereocommunication mode between cyclodextrins and binaphthyls translates into highly responsive chiroptical behavior, […]Giovanni Preda
- Palladium/photoredox catalysis for a decarboxylative radical C(sp3)–C(sp3) cross-coupling reaction of γ-methylidene-δ-valerolactones with alkyl carboxylic acids Tháng 8 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01005E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ran Song, Jiaxing Li, Lin Li, Huaixi Mu, Wei Feng, Daoshan Yang, Wen Si, Jian LvA radical decarboxylative Csp3–Csp3 cross-coupling of γ-methylidene-δ-valerolactones and non-preactivated alkyl carboxylic acids was developed by combining photocatalysis […]Ran Song
- Photocatalytic ketone synthesis: recent advances in radical-based approaches from carboxylic acids and derivatives Tháng 8 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01059D, Review ArticleShengbiao Yang, Xiaochen Wang, Lan Bao, Tianzhen Wang, Lingang Wu, Qingmin WangThis review systematically summarizes the photocatalytic strategies for constructing ketones from carboxylic acids and their derivatives, emphasizing single-electron radical pathways.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Shengbiao Yang
- Structurally Divergent Reactivity of 2,2-Disubstituted Azetidines – Mechanistic Insights and Stereochemical Implications of Amide Coupling and Ring Expansion to 5,6-dihydro-4H-1,3-oxazines Tháng 8 27, 2025
