RSC – Org. Chem. Front. latest articles- Unveiling the mechanisms of gold/copper bimetallic catalysis in the synthesis of complex heterocyclic compounds Tháng 3 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01639H, Research ArticleFengjuan Ma, Qing Sun, Jingxin Hu, Xin Cheng, Huiwen Zheng, Lei Zhou, Xin Lu, Yidong Luo, Ren-Jie SongBimetallic catalysis offers enhanced reactivity, selectivity, and cooperative effects compared to traditional monometallic catalysis. However, the detailed understanding of coordination and metal interactions in such bimetallic systems is still elusive....The […]Fengjuan Ma
- A Divergent Electrochemical Platform for Diazene Radical Generation and C–N Coupling Reactions Tháng 3 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00078A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Roopam Pandey, Suchismita Rath, Yashika Tyagi, Shivani Jadoni, Tejas Prabakar, Shreemad Patel, Debajit Maiti, Subhabrata SenThe development of sustainable methods for controlled C-N bond formation remains a central challenge in modern synthesis. […]Roopam Pandey
- Copper-catalyzed B–H bond insertion reaction of triboranes (L·B3H7) with diazo compounds Tháng 3 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00098C, Research ArticleLei Cao, Jiarui Chang, Xi-Meng Chen, Yan-Na Ma, Xuenian ChenCompared with an enormous amount of reactions of the B-H bond of the Lewis base BH3 adducts, the reactions of the B-H bond of the multinuclear boranes have been less...The content of this RSS Feed (c) The Royal […]Lei Cao
- Site-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones Tháng 3 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00044D, Research ArticleVaibhav Ramachandra Pansare, Sreelakshmi N, Nagaraju BarsuThe direct C–H alkylation of nitrogen-containing heterocycles is a valuable and widely pursued transformation due to the importance of these scaffolds in pharmaceuticals and bioactive natural products. In this study,...The content of this RSS Feed (c) The Royal Society of ChemistryVaibhav Ramachandra Pansare
- Tunable Ring-Opening of 2H-Azirines via Visible-Light-Driven Novel Selective C-C/C-N or C=N Bond Cleavage Tháng 3 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00168H, Research ArticleBao-Gui Cai, Li-Hua Zhang, Yang Xie, Qiong Zhang, Jun XuanThe visible-light-induced ring-opening of 2H-azirines has primarily focused on the selective cleavage of individual bonds, such as C–C, C–N, or C=N. However, simultaneous cleavage of multiple bonds, such as both...The content of this RSS Feed (c) The Royal […]Bao-Gui Cai
- Photocatalyzed regioselective arylation of trialkylamines Tháng 3 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01719J, Research ArticleJiamin Wu, Xin Wang, Kuai Wang, Ling-Guo MengEasily available trialkylamines are increasingly utilized as coupling partners with diverse hydrocarbons to construct various complicated amine frameworks. However, controlling the regioselectivity of these reactions remains a significant challenge. We...The content of this RSS Feed (c) The Royal Society of […]Jiamin Wu
- Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated Tháng 3 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01481F, Research ArticleLong-Jin Zhong, Xuan Shang, Pengfei Huang, Quan Zhou, Changhui Liu, Yu LiuWe report a study on the use of ligated boryl radicals for the synthesis of nitrogen-containing polycyclic compounds under photocatalytic conditions through a halogen-atom transfer (XAT) strategy. This approach leverages...The content of this RSS Feed (c) […]Long-Jin Zhong
- Cu(I)-catalyzed, N-Fluorobenzamides Enabling 1,2-Carbofluorination of Unactivated Alkenes via Free Radical Relay Tháng 3 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01763G, Research ArticleHong Ji, Haifeng Qiao, Boyi Wang, Tianyu Lu, Weixing Chang, Lingyan Liu, Jing LiThe construction of carbon-fluorine bond has always remained challenging. This work described a two-component 1,2carbofluorination bifunctionalization of unactivated alkenes through a free radical relay process. The N-fluorobenzamide was firstly used...The content of this RSS […]Hong Ji
- EtAlCl2 -Promoted Defluorinative Thiolation of α-Trifluoromethyl Alkenes Tháng 3 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00011H, Research ArticleXin Guo, Guoliang Pu, Long Xiao, Jiarui Liang, Hang Zhang, Yu Chen, Yang Huang, Qiuli Yao, Chun-Yang HeHere, we report a EtAlCl2-promoted thiolation of trifluoromethyl alkenes, which leads to the complete substitution of all three fluorine atoms and affords trisubstituted products. Although the transformation proceeds through a...The […]Xin Guo
- Engineering Tetraphenylethene-Based Z and E Stereoisomers: Structural Analysis and Sensing Application Tháng 2 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00075D, Research ArticleHan-Jiang Yang, Yatuan Ma, Xinpei Zhong, Xin Yang, You Xu, Xiaoxue Zhang, Zhixin Xiang, Xiujuan Huang, Wenji Wang, Jinyi Wang, Maosen YuanThe exploration of Z/E stereoisomers represents an interesting and significant endeavor in molecular engineering. We developed three pairs of tetraphenylethylene (TPE) derivatives modified by heteroatom-containing trivalent […]Han-Jiang Yang
- Oxidation Reactions in the Current Total Synthesis of Natural Products Tháng 2 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00050A, Review ArticleJian-Feng Zheng, Anqi Chen, Yan-Jiao Gao, Pei-Qiang HuangOxidation and oxidative reactions are a type of fundamental transformation in organic chemistry, which are indispensable for organic synthesis, especially for the total synthesis of natural products. Although there are...The content of this RSS Feed (c) The Royal Society of […]Jian-Feng Zheng
- Polysubstituted bicyclo-[2.1.1]-hexanes as benzene isosteres for medicinal chemistry Tháng 2 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01662B, Review ArticleEugenio Roà, Quentin LefebvreThis comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Eugenio Roà
- Aryl imidazoisoindoles for intrinsic 10π pericyclic photochromism with nonlinear acid responsiveness Tháng 2 26, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00016A, Research ArticleTaichi Muto, Chigusa Goto, Shohei Katao, Tsuyoshi KawaiNew aryl imidazoisoindoles were synthesized and identified as 10π photochromic systems. Catalytic amounts of acid significantly accelerate the ring-opening reaction, exhibiting nonlinear acid responsiveness.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Taichi Muto
- An air-stable chiral P,N-ligand/PdCl2 partner enables a highly enantioselective oxidative homocoupling of naphthylboronic acids/boronates only in an oxygen atmosphere Tháng 2 26, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01752A, Research ArticleGuo Cheng, Jing-Liang Yu, Qian-Mao Zhang, Zhen-Yu Yang, Fang Tian, Li-Xin WangA highly enantioselective oxidative homocoupling of naphthylboronic acids/boronates was achieved for the first time in the presence of an easily available chiral P,N-ligand/PdCl2 complex only in an oxygen atmosphere at high temperature conditions.To cite this article […]Guo Cheng
- Interactions beyond H-bond: Unveiling the role of unorthodox non-covalent interactions in charged thiourea and its catalytic efficiency Tháng 2 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01735A, Research ArticlePrabhahar Murugan, Parul Rathour, Dipankar Das, Brijesh Patel, Srinu Tothadi, Biswajit Ganguly, Saravanan SubramanianThe development of catalyst with a rapid turnover rate under ambient reaction condition is highly desired. Inspired by the biocatalytic systems, the field of charge-driven catalysis provide useful guidelines for...The content of this RSS […]Prabhahar Murugan
- Enantioselective synthesis of atropisomeric biaryls and heterobiaryls via transition metal-catalyzed cyclization Tháng 2 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01492A, Review ArticleShibo Lin, Ya Zou, Yiwen Chu, Junfeng Deng, Lifeng ZhaoAtropisomeric architectures with a chiral axis are prevalent in biologically active molecules and natural products, and they are widely put to use in privileged catalysts and chiral ligands.To cite this article before page numbers are assigned, use the […]Shibo Lin
- B-spiroBODIPYs as a fluorophore responsive to hydrogen bond donors Tháng 2 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00102E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aiko Kondo, Hideaki Takano, Hiroshi ShinokuboWe demonstrate an Au-catalysed synthesis of B-spiroBODIPYs with a 1,3-dioxinone moiety. The B-spiroBODIPY exhibits solvent-dependent fluorescence arising from hydrogen-bonding interactions, which offers a platform for stimulus-responsive probes.To […]Aiko Kondo
- Divergent Transformations of N-Phenyl-N-tosylfluoroacetamides to Amides and Imides (N-Tosylamides) Tháng 2 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00069J, Research ArticleNan Wang, Xia Chen, Chun-Yan Liu, Zhi-Ying Feng, Ming Bao, Xiao-Yu ZhouThe strained C−N bond of N-phenyl-N-tosylfluoroacetamides is activated via transition-metal-free nucleophilic addition pathway by employing suitable nucleophilic reagents, such as indoles, indolines, aryl amines and carboxylic acids. Based on this,...The content of this RSS Feed (c) […]Nan Wang
- β-and Z-Selective Metal-Free Cyanation of Ynamides: A Direct Approach to Piperidines Fused to Arenes Tháng 2 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00022C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dorian Schutz, Wenwen Yang, Laurence MieschMetal-free βand Z-selective hydrocyanation of terminal ynamides using TMSCN and TBAF is described. The transformation proceeds with excellent regio-and stereoselectivity, delivering exclusively Z-configured tertiary enamides. Treatment with […]Dorian Schutz
- Enantioselective synthesis of allylic boronates bearing a stereodefined (E)-alkenyl chloride by Cu-catalyzed borylation of allylic gem-dichlorides Tháng 2 24, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00061D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrea Chaves-Pouso, Andrés M. Álvarez-Constantino, Patricia Gómez-Roibás, Martín Fañanás-MastralA copper-catalyzed enantioselective and E-selective borylation of allylic gem-dichlorides that affords chiral synthetically versatile γ-chloro substituted allylic boronates is reported.To cite this article before […]Andrea Chaves-Pouso
- Unveiling the mechanisms of gold/copper bimetallic catalysis in the synthesis of complex heterocyclic compounds Tháng 3 4, 2026
