RSC – Org. Chem. Front. latest articles- Direct Alkylation of Quinolines with Organolithium-Activated 1,1-Diborylalkanes Tháng 12 29, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01448D, Research ArticleWoohyun Jo, Changsu Ryu, Jung Woon Yang, Seung Hwan ChoWe report a regioselective alkylation of quinolines enabled by activation of 1,1-diborylalkanes with organolithiums. Direct C2-alkylation occurs in THF with tert-butyllithium, whereas C4-alkylation of C2-substituted quinolines proceeds in toluene with...The content of this RSS Feed (c) The Royal […]Woohyun Jo
- Late-Stage Defluorinative Functionalization: Synthesis of Thioamides and Heterocycles from Trifluoromethylarenes Tháng 12 27, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01574J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marcus Söderström, Esther Oreoluwa Olaniran Håkansson, Luke R OdellWe report the first general strategy for converting trifluoromethylarenes into thioamides and heterocycles through a telescoped two-step, one-pot process. The transformation proceeds via a […]Marcus Söderström
- TBADT/nickel co-catalyzed arylation of hydrosilanes with aryl halides Tháng 12 25, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01479D, Research ArticleKaixin Fu, Zilong Yan, Weiping Zheng, Shengchao Yang, Dong Xing, Yong Lu, Zhaolin Fu, Shuanhu GaoHere we report a nickel/photo co-catalyzed direct radical Si-H arylation of hydrosilanes with aryl halides.Tetrabutylammonium decatungstate (TBADT) serves as a robust hydrogen-atom-transfer (HAT) photocatalyst, working synergistically with a nickel catalyst...The content of […]Kaixin Fu
- Photoinduced Iridium-Cobaloxime mediated Alkene C(sp2)-CF2H Cross-coupling：Difluoromethylation of Ketene dithioacetal Tháng 12 24, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01628B, Research ArticleBaoping Ren, Long Sun, Junsheng Zhi, Qun Liu, Yifei Li, Ling PanThe difluoromethylation of various substrates has experienced significant advancements with the rapid development of photoinduced reactions. However, the difluoromethylation of alkenes are usually limited to addition reactions, the C(sp2)−CF2H construction...The content of this RSS Feed (c) […]Baoping Ren
- Ligand-controlled Copper-catalyzed Carboamination Reactions of Styrenes and 1,3-Enynes to Access Diverse Imides Tháng 12 24, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01504A, Research ArticleQi-Xuan Jiang, Kai Xiao, Wei Huang, Feng-Hua ZhangThe multi-component reaction among alkenes, nitriles and carboxylic acids via the radical Ritter-type process is one of the most convenient and efficient methods for obtaining imides. However, these multi-component reactions...The content of this RSS Feed (c) The Royal Society of […]Qi-Xuan Jiang
- Photoredox Catalyzed Visible Light-Induced Reduction of Nitroarenes into Anilines Tháng 12 24, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01565K, Research ArticleWeiqiang Sun, Hao Guo, Aishun DingA photochemical methodology was developed for the reduction of nitroarenes, utilizing γ-terpinene as the reductant and 9-HTX- as the photocatalyst. This study gave another way to generate 9-HTX- species from...The content of this RSS Feed (c) The Royal Society of ChemistryWeiqiang Sun
- Brønsted acid-catalyzed synthesis of trifluoromethylated azulenes via cyclization of 1-phenyl-2-CF3-1,3-enynes Tháng 12 24, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01617G, Research ArticleWuding Sun, Jimin Yang, Kai Di, Luyang Sun, Shuhui Xu, Dong Li, Jinfeng Zhao, Jingping Qu, Yi Luo, Yuhan ZhouAzulene and its derivatives are important scaffolds with broad applications. The introduction of a trifluoromethyl group is an efficient way to enhance the activity and physicochemical properties of […]Wuding Sun
- Discovery and synthesis of (+)/(–)-muyoquinone A, a pair of rare cyclopropane bridge-containing pentacyclic benzoquinone dimers with cytotoxic activity Tháng 12 23, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01312G, Research ArticleHai-Yan Cao, Cheng Yi, Yu-Wei Niu, Ke-Liang Chen, Yang Liu, Fang-Fang Lai, Yun-Bao LiuThis work reports the structures, total synthesis via the Diels–Alder cascade reaction and cytotoxic activity of (±)-muyoquinone A, a pair of rare pentacyclic benzoquinone dimers isolated from the endophytic fungus Muyocopron laterale.To cite this […]Hai-Yan Cao
- Visible light-driven construction of isoxazoline/isoxazole scaffolds via [2+2+1] cyclization of alkenes with tert-butyl nitrite Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01546D, Research ArticleYanfu Jiang, Jiantao Zhang, Xian Jiang, Renhua Su, Liuzhuang Xing, Xin Yang, Weibing LiuA visible light-driven [2+2+1] cyclization of alkenes with tert-butyl nitrite (TBN) has been developed for the efficient construction of isoxazoline and isoxazole scaffolds. This protocol operates under mild conditions—utilizing ambient...The content of this RSS […]Yanfu Jiang
- Class-II-aldolase-mimicking polyfunctional Lewis acid/azolium–aryloxide catalysts in direct enantioselective nitro-aldol additions Tháng 12 23, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01558H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Khushbu Jangid, Lisa A. Schmoltzi, Alexander Allgaier, Radhika Kataria, Daniel M. Wanner, Justin Herrmann, Janis Gschwind, Silvio Münch, Joris van Slageren, Johannes Kästner, René PetersA polyfunctional Co(II)/azolium–aryloxide catalyst enables direct highly enantioselective […]Khushbu Jangid
- Preparation and Catalytic Properties of Benziodolium Salts Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01379H, Research ArticleHaruhi Hirai, Akira Tsubouchi, Kazunori Miyamoto, Akira Yoshimura, Akio SaitoDibenziodolium salts have recently emerged as useful iodine (III)-type halogen bonding (XB) donors. However, although benziodolium salts with one less benzene ring are expected to exhibit different reactivity from dibenziodolium...The content of this RSS Feed (c) The Royal […]Haruhi Hirai
- Multi-site thiolation enables rapid and precise synthesis of 2-pyridone thioethers Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01352F, Research ArticleXingchi Li, Taoyuan Liang, Guan Huang, Shuangliang Zhao, Zhuan ZhangThe direct and selective functionalization of 2-pyridones remains a fundamental challenge in synthetic chemistry. While conventional strategies targeting the C=C double bond offer some solutions, achieving broad site-selectivity and site-diversity...The content of this RSS Feed (c) The Royal […]Xingchi Li
- Dehydrogenative Aromatization of Cyclohexanone Derivatives for the Synthesis of Site-selective Substituted Phenols and Anilines Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01442E, Review ArticleDahong Jiang, Quanfeng Liang, Haiqing Li, Fang FanAromatic compounds containing phenol or aniline functionalities are ubiquitous building blocks in various fields both in academic and industrial chemistry. Traditionally, substituted phenols and anilines are synthesized via electrophilic or...The content of this RSS Feed (c) The Royal Society of […]Dahong Jiang
- Theoretical Insight: Dual Roles of Electron-Pair Donors and Acceptors in Activating and Mediating Iodine Atom Transfer Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01593F, Research ArticleTaiming Bai, Ming Lei, Hui LiLewis bases (Lbs) act as electron-pair donors and react with BH3 to form Lbs→BH3 complexes. In catalytic systems, these precursors generate two key reactive species: the Lbs→ BH2 • radical...The content of this RSS Feed (c) The Royal Society of ChemistryTaiming Bai
- A Versatile and Practical One-Pot Strategy for a Greener, Waste-Minimized Synthesis of Aryloxy- and Alkyloxy-Substituted Metallophthalocyanines via Tandem SNAr-cyclotetramerization Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01267H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Federica Palmeri, Venanzio Raglione, Laura Mancini, Gloria ZanottiPhthalocyanines represent molecules of considerable scientific interest, yet their synthesis remains challenging, particularly under environmentally sustainable conditions. Due to the increasingly urgent need for developing […]Federica Palmeri
- Isoquinoline-Catalyzed Visible-Light-Mediated 1,2-/1,4-Thiosulfonylation Difunctionalization Reaction of Thiosulfates with Alkenes Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01570G, Research ArticleMolai Zhao, Yang Fu, Min Peng, Ya-Wen Wang, Chuanhua Qu, He Zhong Jiang, Jiahong Li, Rui TanWe have developed a novel method for the 1,2-/1,4thiosulfonylation bifunctional reaction of thiosulfates with nonaromatic olefins. This approach eliminates the need for metal catalysts or photocatalysts, offering an environmentally friendly,...The content […]Molai Zhao
- Asymmetric Transfer Hydrogenation of Polyoxygenated 3-Arylidenechroman-4-ones: A Powerful Tool for the Total Synthesis of Natural Homoisoflavonoids Tháng 12 23, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01629K, Research ArticleJuliane S. Falcão, Marcos V. O. Da Silva, Edivaldo S. Dos Santos Rodrigues, Osvaldo A. Santos-Filho, Paulo Costa, Guilherme S CaleffiA mild and highly efficient one-pot asymmetric transfer hydrogenation (ATH) of challenging, electron-rich 3arylidenechroman-4-ones is reported. The protocol utilizes a Ru(II)-catalyst under neutral conditions (HCO₂Na) to reduce […]Juliane S. Falcão
- Tandem indium(III)-catalyzed cyclization and intermolecular hydrofunctionalization of 1,6-enynes Tháng 12 22, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01388G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Raquel Pérez Guevara, Diego Folgueira Iravedra, Lorena Alonso-Marañon, Montserrat Martínez, José Pérez SesteloA tandem indium(III)-catalyzed cyclization and intermolecular hydrofunctionalization of 1,6-enynes for the stereoselective synthesis of functionalized carbo- and heterocycles is reported. […]Raquel Pérez Guevara
- Theoretical Insights into the Cu-Catalyzed Boronation of Conjugated Trienes: Mechanism and Selectivity Control Tháng 12 22, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01600B, Research ArticleLiyuan Meng, Ran Fang, Simeng Qi, Yuanjun Song, Lizi YangThe copper-catalyzed boronation of conjugated trienes offers a promising route to organoboron compounds but is often limited by selectivity challenges. While previous studies have demonstrated its potential, a detailed mechanistic...The content of this RSS Feed (c) The Royal […]Liyuan Meng
- Radical Reactivity of Aryl Thianthrenium Salts Tháng 12 18, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01417D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ryan A Pohorenec, Shiqing XuFunctionalization of the C(sp2)–H bond is a challenging yet highly useful synthetic task due to its relative inertness and commonality among functional groups. Arene thianthrenation is an emerging […]Ryan A Pohorenec
- Direct Alkylation of Quinolines with Organolithium-Activated 1,1-Diborylalkanes Tháng 12 29, 2025
