RSC – Org. Chem. Front. latest articles- Copper-Catalyzed Radical Aminocyanation of Allenes Tháng 10 17, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01254F, Research ArticleSheng Du, Wei-Qian Fan, Jun-Qi Liu, Ying Tong, Dong-Qing Yang, You-Ren Dong, Hailin Cai, Zhengyu Deng, Tianbo Liu, Wenting WeiThe aminocyanation of allenes remains an uncharted territory in organic synthesis, despite the significant progress in aminocyanation of other unsaturated hydrocarbons. Current amination strategies for allenes suffer from […]Sheng Du
- Helicoselective Assembly of 2-Pyranone-Helicenoids via NHC-Catalyzed [3+3] Annulation Tháng 10 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01328C, Research ArticleJiahui jian wang, shujie Ji, Zhipeng Li, Yuhan Liu, Yani Li, Jian WangHelical frameworks play a vital role in supramolecular chemistry and material sciences. Nevertheless, the scarcity of robust stereoselective methodologies continues to impede their practical development. We herein report an NHC-catalyzed...The content of this RSS Feed […]Jiahui jian wang
- Photocat alytic Synthesis and Closed-Loop Recycling of Poly(semi-aromatic 1,2-ethanediol)s Tháng 10 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01075F, Research ArticleYi-Ming Chen, Yu Liu, Yong-Ze Chen, Yan-Biao KangThe strategy of closed-loop recycling of plastic waste has been recognized as an indispensable access to solving environment problems and relieving resource scarcity. However, the design of new monomer-to-polymer-to-monomer recycling...The content of this RSS Feed (c) The Royal Society of […]Yi-Ming Chen
- Photoredox-Catalyzed Multicomponent 1,2-Difunctionalization of Activated Alkenes with Silyl Enol Ethers and Oxime Esters Tháng 10 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01314C, Research ArticleJia-Yin Wang, Ming-Xian Zhang, Yu Bao, Tao Wang, Shenghu Yan, Yue ZhangThe photoredox-catalyzed multicomponent 1,2-cyanoalkylacylmethylation of electron-deficient alkenes using silyl enol ethers and cycloketone oxime esters has been described. This protocol provides access to alkyl cyanide group-anchored 1,4dicarbonyl compounds with generally...The content of this RSS Feed (c) […]Jia-Yin Wang
- Masked Formylation of Activated Aromatics via Dithianes and a Mild, Sustainable Cleavage Protocol Tháng 10 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01300C, Research ArticleJulia Urbiña-Alvarez, Daniela Torres-Ruiz, Camilo Mahecha-Mahecha, Gabriel Hernandez-Abdallah, Mario A. Macías, Diego Gamba-SánchezHere we describe a masked formylation strategy based on the activation of 1,3-dithiane oxide with oxalyl chloride. The reaction proceeds through a thionium ion intermediate, enabling efficient electrophilic aromatic substitution...The content of this RSS Feed […]Julia Urbiña-Alvarez
- Ligand-centered redox driven Zn(II)-catalyzed anti-markovnikov hydroamination of activated alkenes with primary aromatic amines via aminium radical cations Tháng 10 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01248A, Research ArticleSubhasree Pal, Santana Chakraborty, Afsana Pervin, Nanda D PaulA ligand-centered redox-driven strategy for anti-Markovnikov hydroamination of electron-deficient alkenes including acrylates, acrylonitrile, and acrylamides-enabled by a well-defined Zn(II)-catalyst bearing a redox-active arylazo-phenanthroline ligand is reported.The azo-functionalized ligand serves as...The content of this RSS Feed (c) The Royal Society […]Subhasree Pal
- Synthesis of Aminoalkyl Nitriles through 2-Azaallyl Anions-Driven Cascade Radical Ring-Opening/Intermolecular Coupling Tháng 10 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01353D, Research ArticleYonggang Jiang, Cuirong Qin, Haoqing Tang, Liang Li, Hongbin Zhang, Xiaodong YangAminoalkyl nitriles are common structural motifs in bioactive molecules and they serve as valuable intermediates in synthesis. The preparation of such moieties from radical cascade reactions, however, is rare. Herein...The content of this RSS Feed (c) […]Yonggang Jiang
- Stereoselective synthesis of C-aryl glycosides via radical-enabled 1,4-Ni migration: Glycosyl chlorides as coupling partners Tháng 10 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01241D, Research ArticleHu-Yi Li, Zhi-Jie Niu, Qiao Li, Xi Chen, Xiao-Ping Gong, Xue-Ya Gou, Jinhui Yang, Xue-Yuan Liu, Yong-Min LiangC-Aryl glycosides are important skeleton motifs in medicinal chemistry and biochemistry. However, the stereoselective and efficient construction of structurally complicated C-aryl glycosides under mild conditions remains challenge. Herein, we report...The […]Hu-Yi Li
- Synthesis of Noradamantane Building Blocks Tháng 10 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01150G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthew Todd, Ivana Cisarova, Zdeněk Tošner, Radim HrdinaThe carbon scaffold of noradamantane, a ring contracted adamantane derivative, is notoriously difficult to selectively oxidise and functionalise, which limits the hydrocarbon’s use as a […]Matthew Todd
- Synthesis of thiazoles by desulfurative cyclization/ring expansion cascade reaction of S-azirinyl xanthates: two mechanistically distinct radical pathways Tháng 10 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01233C, Research ArticleDmitrii Sergeevich Vasilchenko, Anastasiya V. Agafonova, Alexander F. Khlebnikov, Nikolai V. Rostovskii, Mikhail Sergeevich NovikovS-Azirinyl xanthates were synthesized as novel 2H-azirine derivatives exhibiting dual reactivity toward free radicals. Carbon-, tin-, and silicon-centered radicals initiate a desulfurization/ring expansion cascade of these compounds to form thiazoles...The content of this […]Dmitrii Sergeevich Vasilchenko
- A Unified Predictive Model for Chiroptical Sensing: A Substrate-Centric Approach to Predicting Circular Dichroism Outputs Across Two Chemically Distinct Organic Classes Tháng 10 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01281C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lorenzo Cracco, Roberto Penasa, Paolo Zardi, Giulia Licini, Manuel Orlandi, Cristiano ZontaThis study presents an innovative approach for rapid and reliable determination of circular dichroism outputs using a chiroptical supramolecular sensor based […]Lorenzo Cracco
- Unravelling the Evolution of Nickel-Catalyzed C-O Bond Activation with Data-Driven Strategies Tháng 10 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00947B, Research ArticleJingyuan ZHU, Yizhou WANG, Imanuel Rava, Shihong Chen, Zhiyan Zou, Yong Huang, Zhenyang Lin, Haibin SuSince the 1970s, nickel has proven to be an exceptionally efficient catalyst for cross-coupling reactions, particularly in the activation of C–O bonds, which serves as an environmentally friendly alternative to...The content of […]Jingyuan ZHU
- Photo-Induced Selective α/γ-Functionalization of Aliphatic Amines via Intramolecular Hydrogen Atom Transfer Tháng 10 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01204J, Research ArticleZhuohua Li, Xiao Zhou, Pengwei Hu, Chao Yang, Lin Guo, Wujiong XiaA general method for site‐selective α/γ‐C(sp3)−H functionalization of amines has been developed. Regioselective activation of inert C−H bonds is achieved by 1,5/1,7‐hydrogen atom abstraction by an oxidatively generated aryl radical....The content of this RSS Feed (c) […]Zhuohua Li
- An electrochemical reductive allylation and alkylation of the carbonyl group in α, β-unsaturated aldehydes and ketones Tháng 10 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01168J, Research ArticleZhihong Qiu, Fan Wang, Hongming Jin, Zhongquan LiuWe report herein an electrochemical reductive allylation and alkylation of the carbonyl groups in α, β-unsaturated aldehydes and ketones. This study provides a practical and efficient new method for synthesizing...The content of this RSS Feed (c) The Royal Society of […]Zhihong Qiu
- Ligand-Free Iron Carbonyl Catalyzed Transfer Hydrogenation Strategy: Synthesis of N-Heterocycles Tháng 10 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01274K, Research ArticleJunhwa Hong, Seok Beom Lee, Seung Hyun Choi, Jinwoo Lee, Honghui Lee, Joonseok Jang, Suckchang HongTransfer hydrogenation (TH) systems have been extensively developed using a variety of metal catalysts. Herein, we report a ligand-free TH protocol that proceeds via iron carbonyl complex catalysis for the...The content of […]Junhwa Hong
- Benzoheterocyclic [b]-fused BODIPYs: synthesis and effects of N, O, and S on structure, photophysical properties, and aggregation Tháng 10 12, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01187F, Research ArticleLimin He, Yanqing Li, Yongli Zhang, Luyan Tian, Yunxia Zhao, Xiaomao Zhou, Shulin Gao, Xiangguang Li, Yanhua Yang, Wei Jiang, Zhaohui WangA one-pot SNAr/C–H activation gave six heteroatom-[b]-fused BODIPYs, clarifying N, O, and S effects on optoelectronic behavior. The dyes show high ΦF, low Knr, and J-aggregation, […]Limin He
- Synergistic Lewis and Brønsted acid-mediated annulation of o-alkynylbenzaldehydes with nitriles for amide-substituted benzo[a]fluorenes Tháng 10 12, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01170A, Research ArticleZan Chen, Rong Xiong, Wenting Huang, Huanfeng Jiang, Wanqing WuA Lewis and Brønsted acid-mediated annulation reaction of o-alkynylbenzaldehydes with nitriles has been developed for the construction of amide-substituted benzo[a]fluorene derivatives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Zan Chen
- DABCO-promoted reaction sequence of β-nitro alcohols and α-oxoaldehydes: construction of diverse tetrahydrofurans and total synthesis of (+)-bruguierol B Tháng 10 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01330E, Research ArticleYu-Xia Lu, Xue-Jiao Lv, Yan-Kai LiuA DABCO-promoted highly efficient reaction sequence has been developed, where β-nitro alcohols reacted smoothly with α-oxoaldehydes to afford diverse tetrahydrofuran derivatives. This strategy enabled the first total synthesis of (+)-bruguierol B.To cite this article before page numbers are assigned, use the DOI […]Yu-Xia Lu
- Chalcogen functionalized pyrimidine synthesis by three-component free radical chalcogenation and pyrimidine ring construction Tháng 10 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01206F, Research ArticleJingfeng Ye, Gengxin Li, Changfeng Wan, Jie-Ping WanThe synthesis of 5-chalcogenated pyrimidines has been achieved via one-step, three-component reactions through cascade C–H chalcogenation and pyrimidine ring construction under transition metal-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Jingfeng Ye
- Photoswitchable anion recognition via synergy between chalcogen bonding and hydrogen bonding Tháng 10 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01341K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Qinhua Rao, Hebo Ye, Peng He, Lei YouThis study presents a reversible photochemical strategy with synergistic noncovalent interactions for controllable anion recognition, offering an effective approach for the development of photo-responsive supramolecular […]Qinhua Rao
- Copper-Catalyzed Radical Aminocyanation of Allenes Tháng 10 17, 2025
