RSC – Org. Chem. Front. latest articles- Pd/Cu/TsOH-Cocatalysed Direct Synthesis of 1,3-Dienyl-2-boronic Acid: A New Reagent for Homoallenylboration Tháng 12 15, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01521A, Research ArticleXiang-Yu Wang, Dao-Jin Ruan, Takuma Sato, Kun Liu, Qin Zhong, Weihua Ma, Tienan Jin, Masahiro Terada, Jian ZhaoThe homoallenylboration of carbonyls and imines using 1,3-dienyl-2-boron reagents is an appealing strategy for accessing synthetically valuable homoallenyl alcohols and amines. Nevertheless, existing reactive 1,3-dienyl-2-boron reagents generally suffer from drawbacks...The […]Xiang-Yu Wang
- Iridium(III)-catalyzed site-selective indole C-H functionalization through enone functionality: design, mechanism and applications Tháng 12 15, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01589H, Research ArticlePisit Nithijarasrawee, Shingo Harada, Tomohiro Isono, Jun Takaoka, Hiroyuki Nakamura, Tetsuhiro NemotoTransition-metal-catalyzed C-H activation has been a powerful platform for straightforward molecular functionalization, yet the mechanistic intricacies often remain elusive. Here, we report an iridium(III)-catalyzed strategy for direct C4-H amination of...The content of this RSS Feed (c) […]Pisit Nithijarasrawee
- A straightforward approach to long forgotten acetophenone-derived bis-Mannich bases: synthesis, mechanistic studies, pharmacophore potential and unique trapping of N-nucleophiles Tháng 12 15, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01329A, Research ArticleEkaterina S. Kudriashova, Margarita A. Yarushina, Ilya I. Vorobyov, Ekaterina A. Fedotova, Elizaveta M. Pnachina, Yuri V. Skornyakov, Alexander V. Mitin, Vsevolod Kuzmichev, Ivan Grishin, Ivan V. Fedyanin, Alexey Yu. Fedorov, Vasilii F. OtvaginAcetophenone-derived bis-Mannich bases, known for their bioactivity and potential to act as Michael acceptors […]Ekaterina S. Kudriashova
- Conformational Rigidity Controlled Copper Catalyzed Chemodivergent Annulation Tháng 12 9, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01518A, Research ArticlePratap Kumar Mandal, Subhra Kanti Mahato, Neelam ., Soumalya Panja, Parikshit Moitra, Amit Kumar SimlandyThe conformational rigidity of substrates is critical in determining reaction outcomes, impacting both reactivity and product selectivity. The impact of conformational rigidity in mechanistic divergence is an area that remains...The content of this […]Pratap Kumar Mandal
- Selective Defluorohydroxylation, Defluoroetherification, and Defluorodifluoromethoxylation of Polyfluoro(hetero)arenes Tháng 12 9, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01434D, Research ArticleXiao-Xiao Sun, Li-Lu Xiao, Li-Ting Xiao, Hao Xu, Zhi-Liang Shen, Mengtao Ma, Xianxian Mao, Xue-Qiang ChuSite-selective defluorofunctionalization of polyfluoro(hetero)aromatic compounds, which can harness the feature of the polyfluoro(hetero)aromatic core while simultaneously introducing valuable functionalities, represents a promising strategy for the synthesis of privileged organofluorides. Herein,...The content of […]Xiao-Xiao Sun
- Controlling Structural and Photophysical Properties in Sequentially Methylated Phenoxazines Tháng 12 9, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01437A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander Huber, Felix Van Der Vight, Viktoria Heising, Christoph Wölper, Oleg Prymak, Hatem M. A. Amin, Kenneth Maly, Jens VoskuhlThe "magic methyl" effect is widely regarded as one of the most extraordinary […]Alexander Huber
- Selective defluorinative [4 + 3] annulation to access fluorinated oxazepines and thiazepines Tháng 12 9, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01324K, Research ArticleFirdous Farah, Akbar Sohail, Ping Jiang, Keyume Ablajan, Shahid Ali KhanWe present a powerful, metal-free annulation that directly transforms α-CF3-styrenes into valuable fluorinated seven-membered heterocycles, including thiazepine and oxazepine frameworks.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Firdous Farah
- Metallic Electrocatalyzed C-N Bond Formations: New Catalytic Modes and Technologies Tháng 12 6, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01467K, Review ArticleZhao-Zhao ZhouThe current state-of-the-art hot research topics for C-N bond formations had focused on versatile and mild transformations. Conventional transition-metal-catalyzed methods were typically conducted with specific ligands, high temperatures as well...The content of this RSS Feed (c) The Royal Society of ChemistryZhao-Zhao Zhou
- Photocatalytic fluoroalkyl radical-initiated construction of fluorinated heterocycles: mechanisms and applications Tháng 12 5, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01484K, Review ArticleDandan Li, Long Chen, Zijia Xiong, Chunmiao Zhao, Xin Wang, Kai SunFluorine-containing heterocycles hold exceptional value across pharmaceuticals, agrochemicals, and materials science owing to fluorine's distinctive electronic effects, lipophilicity, and capacity to modulate bioactivity. Their streamlined synthesis has therefore become a...The content of this RSS Feed (c) […]Dandan Li
- Telescoped continuous flow synthesis of benzimidazoles from o-phenylenediamines and carboxylic acids Tháng 12 5, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01526J, Research ArticleQilin Xu, Zhihao Ma, Fucheng Zhu, Guosi Li, Yidong Zhong, Dong Liu, Yongjun ZangA powerful telescoped continuous flow platform enables the 20-minute synthesis of diverse benzimidazoles with broad scope (32 examples) and gram-scale pharmaceutical applicability.To cite this article before page numbers are assigned, use the DOI form […]Qilin Xu
- Divergent synthesis of spiro or fused indole derivatives tethered with seven-membered rings Tháng 12 4, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01405K, Research ArticleZongkang Wang, Lan Tu, Yawen Lan, Yan Wang, Peng He, Nana Fei, Yakun Jiang, Chengyu Wang, Yanzhong LiAn efficient divergent synthesis of spiro[furan-2,2′-indolines] fused with seven-membered rings and cyclopenta[b]indoles tethered with 7-oxabicyclo[4.1.1]octanes is described.To cite this article before page numbers are assigned, use the DOI form of […]Zongkang Wang
- Bridging terpenyl aldehydes and terpenes with hydrazine Tháng 12 4, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01443C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Li-Ming Zhang, Su-Yang Xu, Xue-Ting Li, Ting-Ting Song, Ding-Wei Ji, Yanhua Lu, Boshun Wan, Qing-An ChenA regio- and chemoselective molecular-bridging strategy for natural terpenyl aldehydes and terpenes with Ts-hydrazine has been developed […]Li-Ming Zhang
- One-pot relay of Staudinger–aza-Wittig and Pd-catalyzed [3 + 2] cycloaddition: modular pyrrolidinone synthesis via in situ generated isocyanates from CO2 Tháng 12 3, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01270H, Research ArticleHong Sun, Mengjiao Yang, Xing He, Duanyang KongWe developed an one-pot relay strategy that combines the Staudinger–aza-Wittig reaction with a Pd-catalyzed [3 + 2] cycloaddition for the modular synthesis of pyrrolidinones under phosgene-free conditions.To cite this article before page numbers are assigned, use the DOI form of […]Hong Sun
- A convenient synthesis of enantioenriched α-haloaldehydes Tháng 12 2, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01415H, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alan J. Brooke, Mathew Sutherland, Robert BrittonWe report a convenient synthesis of α-haloaldehydes involving oxidative cleavage of readily prepared, stable and storable halohydrins. This one-pot process affords α-haloaldehydes in high chemical purity […]Alan J. Brooke
- Recent advances in the total synthesis of polycyclic phloroglucinol natural products Tháng 12 2, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01477H, Review ArticleNa Lv, Chen-Chen Gu, Xin Zou, Long Min, Min-Jing Cheng, Chuang-Chuang LiThe total synthesis of polycyclic phloroglucinol natural products has attracted significant attention from the chemistry community in recent years, owing to their challenging structural frameworks and wide range of biological activities.To cite this article before page […]Na Lv
- Synthesis, twofold oxidative cyclization and dual emission of diaryl-substituted benzodithieno[5.5.5.6]fenestranes Tháng 12 1, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01298H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Man-Kit Lee, Chun-Fai Ng, Dietmar Kuck, Wai-Shing Wong, Hak-Fun ChowDiarylbenzodithieno[5.5.5.6]fenestranes exhibit unusual dual emission (left), but upon twofold formylation and/or oxidative cyclization (right), only monomeric emission occurs.To cite this article before page […]Man-Kit Lee
- Organo-cation-catalyzed site-selective sequential alkylation of dimeric 2-oxindoles: a concise catalytic approach to (+)-calycanthidine and (+)-idiospermuline Tháng 12 1, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01482D, Research ArticlePranay Shyamal, Debabrata Mondal, Arindam Khatua, Saina Shaheeda MK, Alakesh BisaiThe total synthesis of bis(cyclotryptamine) alkaloids has been realized via the development of an organo-cation-catalyzed (C5) site-selective, enantioselective (94% ee) and diastereoselective (dr > 20 : 1) sequential alkylation.To cite this article before page numbers are assigned, use the […]Pranay Shyamal
- Palladium-catalyzed intermolecular 1,3-dienylation of propargyl esters with alcohols for constructing polysubstituted 1,3-dienes Tháng mười một 28, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01350J, Research ArticleShuizhen Lin, Haohao Jiang, Yue Zhang, Ling Jin, Shuoshuo Zhang, Xiaolei HuangWe have developed a palladium-catalyzed propargylic substitution with alcohols as nucleophiles, wherein monohydric alcohols allow the synthesis of 2-alkoxy-1,3-dienes, while the use of diols allows the formation of 1,4-dioxane derivatives.To cite this article before page numbers […]Shuizhen Lin
- A copper-catalyzed cascade borylation/Petasis reaction for synthesis of regioselective 2H-chromenes under catalytic amine conditions Tháng mười một 28, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01398D, Research ArticleXiaoning Yang, Shuyan Wu, Jiayi Wang, Yanqing Peng, Gonghua SongWe present a sustainable one-pot, copper-catalyzed synthesis of 2-phenyl-2H-chromenes with excellent regioselectivity, requiring only a 0.5 mol% catalyst.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Xiaoning Yang
- Correction: Bis-Fischer indole[3,2-b]carbazole modification of [10]cycloparaphenylenes: tuning optical properties through rigid substitution Tháng mười một 28, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO90090E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wanchun Duan, Dongming Chen, Dang Zheng, Shidong He, Wanqun Hu, Lvyuan Hao, Xin XuTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Wanchun Duan
- Pd/Cu/TsOH-Cocatalysed Direct Synthesis of 1,3-Dienyl-2-boronic Acid: A New Reagent for Homoallenylboration Tháng 12 15, 2025
