RSC – Org. Chem. Front. latest articles- Asymmetric [3+2]/[4+2] Annulations for the Synthesis of ε-Sultams Promoted by Bifunctional Base Catalysts Tháng mười một 20, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01474C, Research ArticleChengli Mou, Siyi Chen, Jun Huang, Xin Liu, Liejin Zhou, Shoulei WangHerein, we report a bifunctional hydrogen-bonding organocatalysis that enables the synthesis of chiral ε-sultams through two distinct annulation pathways: a [3+2] cycloaddition between seven-membered cyclic N-sulfonylimines and γ-hydroxy-α,β-unsaturated ketones (C-O...The content of this RSS Feed (c) […]Chengli Mou
- Glycosyl Thiosulfonate-Enabled Ortho-Thiolation via the Catellani Strategy: A Modular Synthesis of Polysubstituted Aryl Thioglycosides Tháng mười một 20, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01342A, Research ArticleZanjila Azeem, Shalini ., Neetu Malya, Ruchir Kant, Sathish Kumar Mudedla, Pintu Kumar MandalSite-selective introduction of a glycosylthiol group into aromatic compounds is a crucial process in organic chemistry.However, the position that a glycosylthiol moiety can be introduced to is largely restricted to...The content of this RSS […]Zanjila Azeem
- π-extended phenothiazines with fused pentagons and hexagons Tháng mười một 20, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01459J, Research ArticleQiyuan Cai, Fengyi Zhao, Dong Jiang, Hiroyasu Sato, Yusuke Yamauchi, Gang Zhang, Weifan WangWhile π-conjugation extension represents an effective strategy to expand phenothiazine derivatives, the fusion of pentagonal and hexagonal rings into the phenothiazine core remains underexplored. Herein, we present a new class...The content of this RSS […]Qiyuan Cai
- A Decade of Advances in Alkynyl Sulfone and Alkynyl Chalcogenide Synthesis Tháng mười một 18, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01359C, Review ArticleDouglas de Castro Vieira, Luiz Henrique Dapper, Rafael Brinkerhoff, Angelita Manke Barcellos, Alex Flores, Gabriel Pereira da CostaOver the past decade, the synthesis of alkynyl chalcogen derivatives has witnessed significant advances. Modern methodologies have increasingly focused on sustainable protocols, catalytic efficiency, milder reaction conditions, and atom-economical processes....The […]Douglas de Castro Vieira
- Reactions of Ketosulfoxonium Ylides with Allylic Carbocations: Stereoselective and Direct Access to Highly-Substituted Cyclopropanes and α-Alkylated Ylides Tháng mười một 18, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01425E, Research ArticleViktor Saraiva Câmara, Marcio Hayashi, Alex S Moraes, Pedro Henrique de Oliveira Santiago, Javier Ellena, Marco Antonio Barbosa Ferreira, Antonio C. B. BurtolosoDespite the well-documented use of sulfur ylides in organic synthesis, the reactivity of α-carbonyl sulfoxonium ylides with carbocations remains largely unexplored. We report the first […]Viktor Saraiva Câmara
- N-Directed, Co-Catalyzed Functionalization of Distal C(sp 3 )-H Bonds with Phenols: Arylation vs. Aryloxylation Tháng mười một 15, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01421B, Research ArticleYu-Han Wang, Hai-Tao Qin, Feng LiuChemo-and regioselective functionalization of free phenols is a continuing challenge. Herein, cobalt-catalyzed cross-dehydrogenative coupling (CDC) of phenols with distal C(sp 3 )-H bonds is achieved. The reaction exhibits good to...The content of this RSS Feed (c) The Royal Society of ChemistryYu-Han Wang
- Gold-Catalyzed Hiyama Coupling of (1-Silyl)allylboronates with Diazonium Salts Tháng mười một 15, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01321F, Research ArticleShan Zhang, Jonas F. Wunsch, Frank - Rominger, Matthias Rudolph, Yaowen Liu, Stephen HashmiThe gold-catalyzed cross coupling of diazonium salts enables the selective coupling of silyl over boryl moieties. So far only aryl and vinyl B,Si-bifunctional building blocks have been coupled to obtain...The content of this RSS […]Shan Zhang
- Origin of Chemo-and Stereoselectivity in NHC-Catalyzed Asymmetric Intermolecular Cycloadditions of Hydrazone and Isatin Tháng mười một 14, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01408E, Research ArticleTingting Shen, Xinghua Wang, Ziyuan Zhou, Donghui WeiDue to the multiple active sites of hydrazine, the origin of chemo-and stereoselectivity for N-heterocyclic carbene (NHC)catalyzed cycloadditions of hydrazone remains unclear. This theoretical study employs density functional theory (DFT)...The content of this RSS Feed (c) The Royal Society of […]Tingting Shen
- Synthesis of azepino[4,5-b]indoles and benzo[f][1,5]diazecine-2,8(1H,3H)diones: promising anti-cancer activity toward cervical and brain cancer Tháng mười một 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01306B, Research ArticleBharat Singh, Suraj Kashyap, Gaurav Goswami, Ashwini Kumar, Prabodh Ranjan, Preeti Chahar, Swapnanil Sen, Ranajit Mal, Ritika Gautam Singh, Manas K. GhoraiA regio- and stereoselective route to azepino[4,5-b]indoles is reported, with unprecedented formation of tetrahydrobenzo[f][1,5]diazecine-2,8(1H,3H)diones. The diazecine compounds show anti-cancer activity against HeLa and U87MG cell lines.To […]Bharat Singh
- Synthesis of benzodiazepine-containing polyheterocyclic compounds via C–H bond activation-initiated formal [5 + 2] annulation Tháng mười một 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01332A, Research ArticleBin Li, Fan Yu, Chenchen Huang, Xinying Zhang, Xuesen FanA novel synthesis of benzodiazepine-containing polyheterocyclics bearing a synthetically valuable vinyl substituent via C–H bond activation-initiated formal [5 + 2] annulation of 2-(indolin-1-yl)-1H-benzo[d]imidazoles with vinyl-1,3-dioxolan-2-one.To cite this article before page numbers are assigned, use the DOI form of […]Bin Li
- A unified mechanistic framework for DDQ-promoted transformation of electron-deficient alkenes: the addition-coupled electron transfer (ACET) perspective Tháng mười một 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01444A, Research ArticleYumiao Ma, Dongtian XuHigh-level computations and experiments reveal that DDQ–alkene oxidations operate on an ACET–AdE2 continuum, providing the first experimental validation of ACET and redefining electron-transfer reactivity beyond the SET paradigm.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Yumiao Ma
- Regiodivergent Gold(I)-Catalysed Rearrangements in Indole Synthesis Tháng mười một 12, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01326G, Research ArticleAna K García-Dueñas, Edson Daniel Herández-Velázquez, Jaime G. Ibarra-Gutiérrez, Rafael Ortiz-Alvarado, Jesús Adrián López, Luis Chacón-García, Gabriel Merino, Fernando Murillo, César R. Solorio-AlvaradoWe report a regiodivergent gold(I)-catalysed cycloisomerisation of terminal 2-alkynyl anilines that affords either C2-o-tolylindoles via a [3,4]-sigmatropic rearrangement or C2/C3-benzylindoles via [1,2]-benzylic migration, where the […]Ana K García-Dueñas
- Cinchona-derived Squaramide Organocatalyzed Asymmetric Domino aza-Friedel-Crafts/Hemiketalization of Acenaphthenequinoneimine and Naphthols Tháng mười một 12, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01238D, Research ArticleYuhong Sun, Hao Wu, Mingshan Zheng, Liming Wang, Ying JinAn unprecedented enantioselective aza-Friedel–Crafts /Hemiketalization of acenaphthenequinoneimine and naphthols have been explored by using cinchona-squaramide catalys. Under the optimized conditions, a range of chiral furanonaphtho-acenaphthene derivatives bearing two vicinal tetra-substituted...The content of this RSS Feed (c) The Royal […]Yuhong Sun
- Copper-catalyzed stereo- and regio-selective decarbonylative alkylation and sequential amination of alkynes with aldehydes and amides Tháng mười một 12, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01356A, Research ArticleKelu Yan, Xiaoyu Wang, Jiangwei Wen, Jianjing Yang, Yuanyuan Zhang, Bingxin Zhou, Daoshan YangA chelate-assisted copper-catalyzed 1,2-alkylamidation of alkynes with aldehydes and amides have been proposed. The generation of high-capacity alkylated enamides exhibits stubborn anti-stereoselectivity and β-regioselectivity.To cite this article before page numbers are assigned, use the DOI […]Kelu Yan
- Scalable manganese-electrocatalytic three-component heteroarene azidoalkylation via a polarity-reversing radical cascade Tháng mười một 12, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01302J, Research ArticleQi-Liang Yang, Zhong-Xu Zhang, Ye Zhu, Zu-Lin Qiao, Xin Liu, Rong Wang, Shu-Xian Liu, Er-Jun Hao, Peng Xiong, Hai-Ming GuoThe first example of an Mn-catalyzed electrochemical three-component Minisci-type reaction of N-heteroarenes with unactivated alkenes and NaN3 via a polarity-reversal pathway is described.To cite this article before page […]Qi-Liang Yang
- Janus-type photo-redox properties and catalytic applications of 5,10-dihydrophenazine derivatives Tháng mười một 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01348H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Phung Phan Huyen Quyen, Nina Hagmeyer, Thanh Huyen Vuong, Adrian Prudlik, Robert Francke, Benjamin Dietzek-Ivanšić, Esteban Mejía5,10-Dihydrophenazine derivatives were synthesized, exhibiting Janus-type reactivity as both photooxidants and photoreductants. They catalyze oxidative C(sp3)–H […]Phung Phan Huyen Quyen
- Organocatalytic enantioselective synthesis of tetrasubstituted chiral allenes via 1,12-addition of alkynyl aza-biphenyl quinone methides formed in situ Tháng mười một 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01403D, Research ArticleChangzhen Zhai, Yuqing Zhang, Boming Shen, Meiwen Liu, Tian Liang, Peiyuan Yu, Yunkun Qi, Wenjun Li, Pengfei LiChiral phosphoric acid catalyzed enantioselective synthesis of tetrasubstituted chiral allenes has been achieved via 1,12-addition of indole-2-carboxylates to alkynyl aza-biphenyl quinone methides formed in situ from α-functionalized alcohols.To cite this […]Changzhen Zhai
- Perimidine directed Rh(III)-catalyzed [4 + 1] and [4 + 2] annulations: synthesis of perimidine linked spiro-succinimides and isoquinolines Tháng mười một 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01292A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vidya Kumari, Lokman H. ChoudhuryA Rh(III) catalyzed perimidine directed C–H activation strategy to achieve [4 + 1] and [4 + 2] annulations with two distinct classes of alkenes for the synthesis of […]Vidya Kumari
- Straightforward and fast access to electrochemical synthesis of selective brominated N-aryl glycine amides Tháng mười một 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01430A, Research ArticleDonghao Wang, Zimei Zhong, Yi Chen, Aifang Wang, Xinyi Huang, Jiabin Shen, Min WangHerein, we report an electrochemical selective bromination of glycine derivatives with tert-butyl bromide.This operationally convenient methodology could enable rapid library generation of brominated or dibrominated N-aryl glycine derivatives.To cite this article before page numbers […]Donghao Wang
- Copper-catalyzed oxidative C–H silylation of BODIPY dyes at the 2- or 2,6-positions with silanes Tháng mười một 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01327E, Research ArticleShuangshuang Zhu, Yunjie Li, Hongdi Yuan, Kangle Liu, Qingbao Gong, Fan LvA novel strategy for the silylation of BODIPYs with silanes has been developed, enabling the facile synthesis of a range of structurally diverse β-silylated BODIPYs with high solid-state fluorescence.To cite this article before page numbers are […]Shuangshuang Zhu
- Asymmetric [3+2]/[4+2] Annulations for the Synthesis of ε-Sultams Promoted by Bifunctional Base Catalysts Tháng mười một 20, 2025
