RSC – Org. Chem. Front. latest articles- Synthesis of non-symmetric ortho-functionalized azoarenes through arylation of arylazo sulfones Tháng 9 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00932D, Research ArticleRayhane Hammami, Victor Flon, Morgane Sanselme, Julien Legros, Isabelle Chataigner, Laetitia Chausset BoissarieA novel protocol for the arylation of arylazo sulfones with organomagnesiums for accessing non-symmetric ortho-functionalized azoarenes has been succesfully developped. Bench-stable substituted arylazo sulfones, which serve as masked electrophilic diazo...The content of this RSS Feed […]Rayhane Hammami
- Nitrosobenzenes as a stepping stone for the development of transition metal and metal-free organic transformations: a comprehensive review Tháng 9 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00842E, Review ArticleNandini R., Ramesh B. DateerNitrosobenzenes are versatile intermediates in organic synthesis. Their NO group on an aromatic ring gives them both electrophilic and nucleophilic character, enabling diverse reactivity in both metal-catalyzed and metal-free transformations.To cite this article before page numbers are assigned, use the DOI form of […]Nandini R.
- Rhodium-Catalyzed Cycloaddition of Bicyclo[1.1.0]butanes with N,N’-Cyclic Azomethine Imines: En Route to Fused Diaza-3D Scaffolds Tháng 9 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01147G, Research ArticleTianlei Du, Qiujie Qin, Jin Li, Yuting Shen, Zixi Wang, Kun Yin, Xinyao Li, Jian Li, Zijun ZhouThe construction of aza-3D frameworks has emerged as a pivotal strategy in drug discovery, owing to their ability to mimic heteroarene bioisosteres. In this study, we introduce a novel strategy...The […]Tianlei Du
- Gold-catalyzed azidation with TMSN3 and mechanistic studies Tháng 9 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01091H, Research ArticleJiawen Wu, Siying Zhao, Xiu-Tian-Feng E, Junfeng Wang, Zhonghua XiaThe growing demand for aryl azides in diverse fields has spurred significant advances in their synthetic methodologies. Herein, we report a gold-catalyzed C–N₃ cross-coupling reaction enabled by ligand-supported Au(I)/Au(III) redox...The content of this RSS Feed (c) The Royal […]Jiawen Wu
- Mechanistic and Machine Learning Insights into Borrowing Hydrogen Reactions Catalyzed by Transition Metal Complexes with N-Heterocyclic Ligands Tháng 9 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01139F, Research ArticleHui-Qi Mo, Cheng HouPyrazole-based transition metal complexes have attracted increasing attention in borrowing hydrogen (BH) reactions, particularly when employing the metal–ligand cooperation (MLC) strategy to achieve high activity and selectivity. However, a systematic...The content of this RSS Feed (c) The Royal Society of ChemistryHui-Qi Mo
- Nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo compounds as N-terminal electrophiles: direct access to novel functionalized hydrazones Tháng 9 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00885A, Research ArticleVarun Anand, Ruchir Kant, Namrata RastogiThe nucleophilic addition of sulfoxonium ylides to hypervalent Iodine diazo reagents as N-terminal electrophiles leads to highly functionalized hydrazones. The operational simplicity, wide scope, high product yields and mild conditions are notable features of the methodology.To cite this article before page numbers […]Varun Anand
- Alkyne-Inserted Tetraphenylethylene Derivatives: Enhanced Aggregation-Induced Emission via Intramolecular and Intermolecular Interactions Tháng 9 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01158B, Research ArticleYi-Yun Zhu, Wenhao Li, Yan-Qi Fan, Hao-Chen Lu, Donghui Wei, Xuenian ChenSolid-state luminescence is often hindered by aggregation-caused quenching (ACQ), prompting the search for efficient aggregation-induced emission (AIE) materials. Tetraphenylethylene (TPE), a star molecule in AIE research, has been widely used...The content of this RSS Feed (c) […]Yi-Yun Zhu
- Regioselective Formation of Naphtho[2,1-b]selenophenes via Cascade Cyclization of 1,3-Diynylpropargyl Alcohols Promoted by Iron(III) Chloride and Diorganyl Diselenides Tháng 9 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01195G, Research ArticlePedro Pauletto, Davi Back, Cristina Nogueira, Gilson ZeniThis manuscript reports a selective diorganyl diselenide/iron(III)-promoted strategy for the synthesis of selenium-containing heterocycles, specifically naphtho[2,1-b]selenophene derivatives, via cascade cyclization reactions.Using 1,3diynylpropargyl alcohols as key substrates and diorganyl diselenides as...The content of this RSS Feed (c) The Royal Society of […]Pedro Pauletto
- Cu-Catalyzed Cyanoalkyl-Alkynylation of gem-Disubstituted Alkenes to Construct All-Carbon Quaternary Center Tháng 9 10, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01138H, Research ArticleYuhang Luo, Xiangxiang Li, Xinjie Zhao, Baomin Yang, Yubo Wei, Guiping QinA copper-catalyzed cyanoalkyl-alkynylation of gem-disubstituted alkenes for the construction of the alkynyl all-carbon quaternary center is reported herein. This protocol enables the efficient synthesis of various cyano compounds with an...The content of this RSS Feed (c) […]Yuhang Luo
- 1,6-Hydrosulfonylation of p-Quinone Methides Enabled via Strain-Release-/Aromaticity-Driven Alkyl Radical Generation and SO2-Capture: Synthesis and Antiproliferative Studies of Sulfonylated Diarylmethanes Tháng 9 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00981B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dipun Kumar Penthi, Tonish Kumar Sahu, Rahimuddin Khan, Shanti Gopal Patra, Tabrez KhanThe integration of γ-keto sulfones, despite being a medicinally relevant building block with the bioactive diarylmethane motif, remains elusive. On […]Dipun Kumar Penthi
- AgOTf-promoted transetherification of p-methoxybenzyl ethers with allyl and benzyl bromides Tháng 9 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00945F, Research ArticleYufan Yang, Dongyang Jiang, Xuan Li, Juxi Wang, Lu Gao, Wanshu Wang, Zhenlei SongAn AgOTf-promoted transetherification of p-methoxybenzyl ethers with allyl and benzyl bromides is reported. It features an unusual C–O/C–Br σ-bond metathesis via an oxonium intermediate, distinct from typical C–O/O–H or C–O/C–O σ-bond metathesis.To cite this article before […]Yufan Yang
- Highly stereoselective synthesis of N-sulfonyl amidines with calcium carbide as an acetylene source Tháng 9 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01010A, Research ArticleRui An, Weihao Cui, Peiming Gu, Meng-Xue WeiA practical and convenient approach for the highly stereoselective synthesis of N-sulfonyl amidines via a one-pot multi-component cascade reaction of sulfonyl azides, amines, water, and calcium carbide as an acetylene source has been developed.To cite this article before page numbers […]Rui An
- Electrochemical water activation for the oxidative cleavage of alkenes Tháng 9 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00944H, Research ArticleNing Zhang, Hui Zhou, Guojuan Liang, Gaochen Liu, Xing Liu, Pengfei Zhou, Dong Zhang, Jing ZhouElectrochemically activated water mediates sustainable oxidative cleavage of both activated and unactivated alkenes without external oxidants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Ning Zhang
- Electrophilic insertion and ring growth in 1,2,5-azadiborolidines: theoretical evidence for boron-driven expansion Tháng 9 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01081K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Victor A. Lucas-Rosales, Miguel A. Vázquez, Gabriel Merino, Albert Poater, J. Oscar C. Jiménez-HallaDFT calculations predict endocyclic CO insertion in 1,2,5-azadiborolidines followed by dimerization and double [1,2]-migration, defining a fourth class of […]Victor A. Lucas-Rosales
- Streamlined synthesis of meta- or para-substituted triphenylamine[3]arenes and their hierarchical assembly into polyhedral cages Tháng 9 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01089F, Research ArticleWangjian Fang, Xin Li, Audrey Nathania Johan, Yimin Zhang, Guoqiang Jiang, Andrew C.-H. SueAn efficient synthesis of meta- or para-substituted triphenylamine[3]arenes is achieved using bromo- or ester-substituted triphenylamine monomers via a BF3·Et2O-catalysed one-pot Friedel–Crafts cyclization with paraformaldehyde.To cite this article before page numbers are assigned, use the […]Wangjian Fang
- Wavelength-tuned, photocatalytic chemoselective hydrodefluorination Tháng 9 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01012H, Research ArticleMeng Guo, Zhi-Peng Ye, Yong-Qing Ye, Xiao-Qing Chen, Kai Chen, Hua YangA chemoselective hydrodefluorination of trifluoroacetamides enabled by switching the SET/EDA pathway through simply tuning the wavelength of irradiation, delivering the corresponding CFH2 and CF2H analogues selectively.To cite this article before page numbers are assigned, use the […]Meng Guo
- Facile N-directed Ru-catalyzed C(3)–H acylation of heterocyclopentadienes with acyl chlorides Tháng 9 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00965K, Research ArticleKonstantin E. Shepelenko, Irina G. Gnatiuk, Andrey A. Aleksandrov, Mikhayl E. Minyaev, Victor M. Chernyshev, Valentine P. AnanikovA Ru-catalyzed C3–H acylation of 2-substituted heterocyclopentadienes with acyl chlorides, compatible with various N-directing groups. The reaction proceeds via rate-limiting C–H activation step, facilitated by in situ-generated carboxylate.To cite this […]Konstantin E. Shepelenko
- Site selective Heck arylation of N-vinyl-7-azaindole engineered by N-oxide activation: scope and mechanistic studies Tháng 9 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00976F, Research ArticleSusanta Patra, Arunava Sengupta, Parthasarathi DasExternal ligand-free Pd-catalyzed arylation achieving an exclusive switch in regioselectivity from α- to β position of N-vinyl-7-azaindoles via an N-oxide activation strategy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Susanta Patra
- Contributors to the Organic Chemistry Frontiers Emerging Investigator Series 2024 Tháng 9 3, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90065D, ProfileThis editorial showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator series.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
- Rh(III)-catalyzed cascade cyclization of enaminones with diazo compounds: switchable syntheses of 2-pyrones and pyrido-quinazolinones Tháng 9 2, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01086A, Research ArticleHongxiang Huang, Ruimeng Zhang, Leiqing Fu, Jie-Ping WanThe Rh-catalyzed C–H activation of N-pyridinyl enaminones and cascade cyclization with diazo compounds are reported to construct 2-pyrones and pyrido-quinazolinones by designing the directing group strategy.To cite this article before page numbers are assigned, use the DOI form of citation […]Hongxiang Huang
- Synthesis of non-symmetric ortho-functionalized azoarenes through arylation of arylazo sulfones Tháng 9 16, 2025
