RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Design and application of a fluorescent probe for imaging of endogenous Bruton’s tyrosine kinase with preserved enzymatic activity Tháng Hai 20, 2025
  RSC Chem. Biol., 2024, Accepted ManuscriptDOI: 10.1039/D4CB00313F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Valaka, Hampus Nyström, Liliana Håversen, Carlos Benitez-Martin, Clara Schäfer, Jang Woo Suk, Alessandro Camponeschi, Joakim Andréasson, Jan Borén, Morten GrotliFluorophore integration into proteins within living cells is essential for exploring proteins in […]
  Anna Valaka
• Three- and four-stranded nucleic acid structures and their ligands Tháng Hai 19, 2025
  RSC Chem. Biol., 2024, Accepted ManuscriptDOI: 10.1039/D4CB00287C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yoshiki Hashimoto, Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke MiyoshiNucleic acids have the potential to form not only duplexes, but also various non-canonical secondary structures in living cells. Non-canonical structures play regulatory […]
  Yoshiki Hashimoto
• Functionalization of a versatile fluorescent sensor for detecting protease activity and temporally gated opioid sensing Tháng Hai 18, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00276H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jennifer Sescil, Hailey Fiel, Steven M. Havens, Emma Fu, Xingyu Li, Kayla E. Kroning, Isabel Solowiej, Peng Li, Wenjing WangGenetically encoded fluorescent sensors have been widely applied to detect cell signaling molecules and […]
  Jennifer Sescil
• Covalent functionalization of G protein-coupled receptors by small molecular probes Tháng Hai 14, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00294F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bert L. H. Beerkens, Adriaan P. IJzerman, Laura H. Heitman, Daan van der EsIn this review, we take a closer look at the most recent small molecular probes that covalently label G […]
  Bert L. H. Beerkens
• Decoding allosteric landscapes: computational methodologies for enzyme modulation and drug discovery Tháng Hai 14, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00282B, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ruidi Zhu, Chengwei Wu, Jinyin Zha, Shaoyong Lu, Jian ZhangAllosteric regulation is a fundamental mechanism in enzyme function, enabling dynamic modulation of activity through ligand binding at sites distal to the active […]
  Ruidi Zhu
• The evolution and application of RNA-focused small molecule libraries Tháng Hai 13, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00272E, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amirhossein Taghavi, Noah A. Springer, Patrick R. A. Zanon, Yanjun Li, Chenglong Li, Jessica L. Childs-Disney, Matthew D. DisneyHits identified from screening diverse compound libraries against RNA targets can be used to […]
  Amirhossein Taghavi
• Chemical approaches to explore ubiquitin-like proteins Tháng Hai 12, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00220B, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Reem Mousa, Dana Shkolnik, Yam Alalouf, Ashraf BrikThis review outlines the chemical toolbox for preparing Ubls and their modified analogs, offering researchers a valuable resource that encourages the use of these methods […]
  Reem Mousa
• Protein ligation for the assembly and study of nonribosomal peptide synthetase megaenzymes Tháng Hai 7, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00306C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Angelos Pistofidis, T. Martin SchmeingNRPS modules are expressed and complexed with substrate analogues separately then ligated to stall at a specific catalytic step, investigated using crystallography.To cite this article before page numbers are […]
  Angelos Pistofidis
• Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha Tháng Hai 6, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00267A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhen Xu, Akesh Sinha, Darpan N. Pandya, Nicholas J. Schnicker, Thaddeus J. WadasThe single domain antibody, I3, interacts with fibroblast activation protein alpha through its CDR3 loop and FR2 region to bind a […]
  Zhen Xu
• Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia Tháng Hai 4, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00243A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Takafumi Kasai, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Ryosuke Kojima, Kenjiro Hanaoka, Yasuteru UranoWe have developed T-azoJSiR640 as a NIR fluorescence probe for severe hypoxia. In contrast to existing NIR probes for hypoxia, […]
  Takafumi Kasai