RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• A Cell-based High Throughput Screening by a Target-NanoLuc Fusion Construct to Identify Molecular Glue Degraders of c-Myc Oncoprotein Tháng 9 7, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00093A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Muyu Xu, Jinying Qiu, Lin Tan, Jiayu Xu, Yi Wang, Wenyue Kong, Hongda Liao, Anran Chen, Xiaolan Chen, Jiying Zhang, Cookson K. C. Chiu, Meiying Zhang, Yingying Tian, Caohui Li, Biao Ma, Leiming […]
  Muyu Xu
• Sources of mismeasurement of RNA knockdown by DNAzymes and XNAzymes Tháng 9 7, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00182J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria J Donde, Alicia Montulet, Alexander TaylorRNA-cleaving olignucleotide catalysts composed of DNA and/or nucleic acid analogues (DNAzymes, modified DNAzymes and XNAzymes) are promising agents for specific knockdown of disease-associated RNAs. However, we and […]
  Maria J Donde
• Deciphering protein long-chain S-acylation by mass spectrometry proteomics strategies Tháng 9 7, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00146C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marc Pieter Baggelaar, Anneroos E. Nederstigt, Samiksha SardanaLong-chain protein S-acylation, the reversible attachment of fatty acids such as palmitate to cysteine residues via thioester bonds, is a widespread post-translational modification that plays […]
  Marc Pieter Baggelaar
• Photoresponsive molecular tweezers modulate Taspase 1 activity Tháng 9 4, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00069F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Antonio L. Figueroa Bietti, Alisa-Maite A. Kauth, Katrin Hommel, Mike Blueggel, Laurenz Mohr, Felix C. Niemeyer, Christine Beuck, Peter Bayer, Shirley K. Knauer, Bart Jan Ravoo, Thomas Schrader“Claws Out!”: Molecular tweezers equipped with […]
  Antonio L. Figueroa Bietti
• 19F NMR-Tags for Peptidyl Prolyl Conformation Analysis Tháng 9 3, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00118H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.George S. M. Hanson, Faidra Batsaki, Teagan L Myerscough, Kristin Piché, Ariel Louwrier, Christopher CoxonProline cis/trans isomerism plays an important role in protein folding and mediating protein-protein interactions in Short Linear Interacting Motifs […]
  George S. M. Hanson
• Biosynthesis of sydonol reveals a new bisabolene cyclase and an unusual P450 aromatase Tháng 9 3, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00213C, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Peiyu Lu, Ling LiuIn this work, the biosynthetic gene cluster and the assembly line of sydonol was discovered and identified, which significantly revealed two unusual chemical conversions catalyzed by a new bisabolene cyclase...The […]
  Peiyu Lu
• Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure Tháng 8 31, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00116A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Erdinc SezginLabeling the plasma membrane is challenging due to probe internalization, photobleaching, and signal loss. We compared lipid-based probes and identified a superior one that efficiently labels membranes in live, fixed, and permeabilized […]
  Erdinc Sezgin
• The bacterial stress response polymerase DinB tolerates sugar modifications and preferentially incorporates arabinosyl nucleotides Tháng 8 31, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00100E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christina M. Hurley, Jeffrey M. Kubiak, Michael B. Cory, Jared B. Parker, Christian E. Loo, Laura C. Wang, Rahul M. KohliThe promiscuous bacterial DNA polymerase DinB tolerates a subset of sugar-modified NTPs, offering […]
  Christina M. Hurley
• Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism Tháng 8 31, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00169B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nan Zhang, Kah Chee Pow, Lanfang Chen, Quan HaoSirtuins are an evolutionarily conserved family of NAD⁺-dependent deacylase whose catalytic mechanism remains actively investigated. While previous studies have captured sirtuin reaction intermediates using thioacetyl-lysine […]
  Nan Zhang
• Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria Tháng 8 25, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00092K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Montserrat Mora-Ochomogo, Mitchell A. Jeffs, Josephine L. Liu, Christopher T. LohansThe development and application of a luminescence assay to quantitatively investigate factors that impact antibiotic sheltering by resistant bacteria.To cite this article before […]
  Montserrat Mora-Ochomogo