RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection Tháng 2 26, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00242G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isabella E Pellizzari-Delano, Trinity H Tooley, Debanjana Mondal, Keya Jani, Carla E Gallardo-Flores, Che C ColpittsBroad spectrum antivirals are critical to respond rapidly to the threat posed by newly emerging RNA viruses. One […]
  Isabella E Pellizzari-Delano
• Discovery of natural products that modulate signaling in patient-derived cells Tháng 2 25, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00203F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Joseph A. Balsamo, Hannah L. Thirman, Kathryn E. Penton, Jordan T. Froese, Benjamin J. Reisman, Sierra M. Lima, Madeline J. Grider-Hayes, Chad R. Potts, Jonathan M. Irish, P. Brent Ferrell, Brian O. BachmannMany […]
  Joseph A. Balsamo
• Structure and characterisation of CMP-Kdn synthetase from the haptophyte microalgae Prymnesium parvum Tháng 2 25, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00285K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Claire Morley, Alexandra J. Munro-Clark, Ben A. Wagstaff, Irina Ivanova, Evgenia Dubinskaya, Ava Rostock, Mary Ortmayer, Colin W. Levy, Robert A. FieldStructural characterisation of a Kdn specific sialic acid synthetase, which can be […]
  Claire Morley
• Bifunctional glycolipids targeting TLR4‧MD-2 and short pentraxins Tháng 2 24, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00324E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniele Zucchetta, Lena Nuschy, Simon Gumpelmair, Peter Steinberger, Iain B. H. Wilson, Holger Heine, Alla ZamyatinaInnate immune detection of pathogen- and danger-associated molecular patterns (PAMPs/DAMPs) centres on pattern-recognition receptors, with the TLR4/MD-2 complex […]
  Daniele Zucchetta
• Folded-State Compatibility and Unfolded-State Constraint Govern Staple-Based Stabilization: Guidelines from a Coiled-Coil Model Tháng 2 24, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00326A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samantha C. Hatfield, Alexa N. Mattingley, Kayla K. Sujeta, Logan D. Humphrey, Taylor Crook, Hiram Aranda, Christian H. Freckleton, Joseph V. Clayson, Chase Renstrom, Joshua L. PricePeptide stapling has emerged as a powerful […]
  Samantha C. Hatfield
• Fluorescent Cationic Fluorinated Oxazoliniums for Cysteine Bioconjugation via S N Ar Reaction Tháng 2 20, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00289C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Karen Ka-Yan Kung, Yosephine Tania Limanto, Ajcharapan Tantipanjaporn, Jie-Ren Deng, Lai- Yi Tsang, Man Kin WongUsing cationic fluorinated oxazolinium compounds, fluorescent cysteine-selective SNAr bioconjugation proceeds under mild conditions, resulting in fluorescent-labelled peptides and […]
  Karen Ka-Yan Kung
• Development of a transcription factor-based biosensor strain for reporting α-terpineol production via the alcohol-dependent hemiterpene pathway in Escherichia coli Tháng 2 18, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00310E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Catherine A. Odhiambo, Isaac A. Ali, Gavin J. WilliamsDevelopment of a genetically-encoded biosensor enabled reporting production of α-terpineol in an engineered E. coli strain.To cite this article before page numbers are assigned, use […]
  Catherine A. Odhiambo
• ILLUMINATING MICROTUBULAR FUNCTION WITH SMALL MOLECULES: PAST, PRESENT AND FUTURE OF FLUORESCENT TUBULIN-BINDING PROBES Tháng 2 11, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00321K, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rebeca París-Ogáyar, Daniel Lucena-Agell, Karl-Heinz Altmann, Valle Palomo, J. Fernando DiazDeveloping tools for the real-time visualization of tubulin, microtubules, and their dynamics has been essential for studying key cellular processes such as […]
  Rebeca París-Ogáyar
• Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures Tháng 2 10, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00302D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alva Abrahamsson, Sakina Khwaja, Andreas Berner, Rabindra Nath Das, Koit Aasumets, Namrata Chaudhari, Sjoerd Wanrooij, Erik ChorellG4-ligands with varying chemical profiles were incorporated into G4-ligand conjugated oligonucleotides (GL-Os) and evaluated for G-quadruplex binding […]
  Alva Abrahamsson
• Covalent targeting of PSMD14 by Eupalinolide B induces oncoprotein degradation and apoptosis in acute promyelocytic leukemia cells Tháng 2 4, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00197H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zheng Chu, Liting Xu, Honglin Chen, Tianyun Fan, Xueqian Hu, Yin Kwan Wong, Qiaoli Shi, Junzhe Zhang, Chengchao Xu, Jigang Wang, Huan TangEupalinolide B covalently targets PSMD14, inhibiting its deubiquitinase activity. This leads […]
  Zheng Chu